| Background: Pu’er tea is a unique microbial fermented tea that has many beneficial chemical components for the human body.Its health benefits are favored by people in the country.In recent years,more and more researches on Pu’er tea have been carried out,and its research on regulating blood sugar and blood lipids has been carried out.It is a hot spot,which provides new care for type 2 diabetes and improves symptoms.Intestinal short-chain fatty acids(SCFA)are produced by carbohydrates that have not been digested and absorbed by the intestinal microflora and play an important role in different metabolic processes in the human body.Some studies have found that SCFA and type 2 The balance of energy metabolism in diabetes is closely related to the regulation of gastrointestinal hormone secretion,insulin sensitivity,and glucose and lipid metabolism through binding to its receptors.Objective: To evaluate the role of Pu-erh tea in improving glyco-lipid metabolism and pancreatic islet function in patients with pre-diabetes.Gas chromatography-mass spectrometry(GC-MS)technique was used to determine the effect of drinking Pu-erh tea on short-chain fatty acids in the intestine of pre-diabetic patients.Methods: 24 pre-diabetic patients(in line with the WHO 1999 diagnostic criteria)from the Endocrinology Clinic of the Second Hospital of Jilin University from February 2016 to May 2017 were enrolled in this study.None of the patients had any hypoglycemic agents treatment.Patients with pre-diabetes were randomly divided into drinking group(4 males,8 females,aged 39-63 years,mean 51.4 ± 7.2 years)and control group(5 males and 7 females,aged 35-64 years,mean 52.8 ± 8.3 years old),drinking tea group patients drink 200ml-300 ml warm water deployment of 1g Pu-erh tea powder,3 times a day for 12 weeks.Patients in the control group drank 200-300 ml of warm water three times a day for 12 weeks.During the study Zhu Huanzhe low-fat diet,exercise daily for at least 30 minutes,weekly telephone follow-up 1,followed by patients drinking tea,drinking water and diet movements.All pre-diabetic patients underwent fasting blood,feces and OGTT before and 12 weeks after the study.Blood samples were taken for blood glucose,lipids,and pancreatic islet function.Gas chromatography-mass spectrometry(GC-MS)was used to detect short-chain Fatty acids include acetic acid,propionic acid,butyric acid,isobutyric acid,valeric acid,isovaleric acid and the like.The statistical analysis of the results using SPSS 21.0 statistical software to complete.Results: 1.After 12 weeks of treatment,the blood sugar,total cholesterol and low density lipoprotein in the Pu’er tea group were significantly lower than those before treatment(P <0.05),but there was no significant change in the control group during the study period.2.Compared with the control group,the levels of insulin secretion increased significantly(P = 0.031,p = 0.049)at 1 hour and 2 hours after the meal in the Pu-erh tea group.The levels of serum C-peptide increased significantly at 1 hour and 2 hours after the meal p = 0.013,p = 0.001).3.Puer tea significantly increased the concentration of butyric acid(p = 0.004)and total amount of SCFAs(p = 0.006)in feces of pre-diabetic patients,while the SCFAs concentration decreased in the feces of the control group,but the difference was not statistically significant.Conclusions: Drinking Pu-erh tea can reduce postprandial blood glucose,serum total cholesterol and low density lipoprotein levels in patients with pre-diabetes and improve islet function.At the same time,drinking pu-erh tea can increase the concentration of butyric acid in intestinal tract and the total content of SCFAs in pre-diabetic patients.This study suggests that Pu’er tea may improve glucose and lipid metabolism in pre-diabetic patients by regulating SCFAs metabolism in the intestine. |
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