Observation On The Effect Of Lifestyle Intervention On Nonalcoholic Steatohepatitis

BackgroundNonalcoholic fatty liver disease has been more and more diagnosed all over the world,and has become the most common chronic liver disease,and has received extensive attention.Fibrosis can occur in patients with nonalcoholic steatohepatitis.FibroScan has high sensitivity and accuracy to liver fibrosis and steatosis,and has no damage to the liver.It has been applied in clinic in recent years.However,the application of FibroScan detection index to evaluate the treatment of non-alcoholic steatohepatitis by lifestyle intervention is rarely reported.ObjectiveTo observe the status survey on nonalcoholic fatty liver disease and the effect of lifestyle intervention on human body composition,liver fibrosis,liver fatty change and liver enzyme in patients with nonalcoholic steatohepatitis.Method1.188 patients with NAFLD diagnosed by B ultrasound and 188 healthy patients who had come to the hospital for medical examination.Among them,30 NASH patients were subjected to lifestyle interventions.2.The body composition analyzer was used to determine the body composition,the controlled attenuation parameter(CAP)and liver hardness value(LSM)were measured using the FibroScan 502,and alanine aminotransferase(ALT),aspartic acid aminotransferase(AST)were measured and other laboratory indicators.3.Using a food frequency survey questionnaire to conduct a dietary survey.4.Lifestyle interventions:Including dietary control and exercise,setting a weight loss target of 5%to 10%,and lifestyle interventions for 3 months.5.Statistical processing:Using SPSS 17.0 software for statistical analysis,measuring data to indicate that the two groups of averages are compared and applied t-tests.The comparison of the count data is tested by ?2.The correlation of the two variables is based on the Spearman level correlation.P<0.05 as significant difference.Result1.NAFLD compared with control group(1)The weight,BMI,ALT,blood sugar(BG),triglyceride(TG),cholesterol(CHOL),low density lipoprotein(LDL)1,very low density lipoprotein(VLDL),and uric acid(UA)of patients with NAFLD were higher than those of the control group.The difference was statistically significant(P<0.05).(2)The proportion of energy,protein,fat,carbohydrates,cholesterol,total fatty acids and saturated fatty acids(SFA)consumed by NAFLD patients was significantly higher than that of the control group,and the proportion of monounsaturated fatty acids(MUFA)and polyunsaturated fatty acids(PUFA)were significantly lower than that of the control group.The difference was statistically significant(P<0.05).2.NASH compared with control group(1)The weight,BMI,LDL,VLDL,and UA of patients with NASH were higher than those of the control group.The difference was statistically significant(P<0.01).Male NASH patients were younger than control group.The difference was statistically significant(P<0.01).(2)The proportion of energy,fat,total fatty acids and SFA consumed by NASH patients was significantly higher than that of the control group,and the proportion of PUFA was significantly lower than that of the control group.The difference was statistically significant(P<0.05).3.NASH and NAFL comparison(1)Male NASH patients are significantly younger than NAFL patients,and CHOL and LDL are higher than NAFL patients.The difference was statistically significant(P<0.05).(2)The visceral fat level of male NASH patients was lower than that of NAFL patients,and the fat rate of the trunk was higher than that of NAFL patients.The difference was statistically significant(P<0.05).(3)NASH patients consume more energy and fat than NAFL patients.The difference was statistically significant(P<0.05).4.Lifestyle Intervention NASH(1)The prevalence rate of NASH is 25.54%,and the prevalence rate of male patients is higher than that of female patients.The difference was statistically significant(?2=8.057,P=0.005).(2)After lifestyle intervention,the patient's weight,BMI,body fat rate,waist circumference,waist height ratio,trunk fat rate,visceral fat level,CAP value,LSM value,ALT,and AST were all significantly reduced.The difference was statistically significant(P<0.05).Conclusion1.NAFLD had different degrees of increase in weight,BMI,BG,TG,CHOL,LDL,VLDL,and UA in the control group.2.NAFLD consumed more energy,protein,fat,carbohydrates,cholesterol,and total fatty acids than control groups.At the same time,the proportion of SFA increased,while the proportion of MUFA and PUFA decreased,and the number of energy and fat intake in NASH patients increased.3.Lifestyle interventions can effectively improve obesity and overweight in NASH patients.4.Lifestyle interventions can effectively reduce the CAP and LSM values of NASH patients,but the improvement of LSM in patients with cirrhosis is not significant.5.Lifestyle interventions can effectively reduce liver enzyme levels in NASH patients.