Characteristics Of Cognitive Impairment And Brian Resting-state Functional Magnetic Resonance Imaging In Vascular Cognitive Impairment No Dementia

Objectives The amplitude of low frequency fluctuation(ALFF)of resting-state functional magnetic resonance(rs-fMRI)and neuropsychological scales was used to study characteristics and correlation of cognitive impairment and cerebral spontaneous activity in patients with subcortical ischemic vascular disease(SIVD)at the stage of vascular cognitive impairment-no dementia(VCIND).Methods All the patients who complained of cognitive impairment from Neurology Department of Tangshan Workers' Hospital during December 2016 to January 2018 were enrolled in this study.Clinical data were collected such as general demographic data of patients,medical history,personal history,family history.Neurophysical examination,laboratory examination,neuropsychological scale assessment and routine MRI examination were performed on all patients.A total of 9 cases with VCIND(VCIND group)and 10 cases healthy controls(NC group)were enrolled and performed rs-fMRI.Comparing the scores of neuropsychological scale between the two groups.The rs-fMRI data of all the subjects was processed and analyse by DPARSF software package to get the whole brain ALFF values.The cerebral spontaneous activity were compared between two groups.The correlation between the scores of neuropsychological scales and ALFF values of the whole brain in VCIND group were evaluated.Results 1 There was no significant difference between the two groups in gender,age,education,medical history and family history(P>0.05).2 The total scores of MoCA and MMSE,AVLT immediate memory,delayed memory and recognition average scores in VCIND group was lower than NC group,the difference was statistically significant(P<0.05).The average scores of visual space and executive ability,attention,language,abstract ability and delayed recall of MoCA scale in VCIND group were lower than those in NC group except naming and orientation,the difference was statistically significant(P<0.05).3 Compared to NC group,patients with VCIND showed decreased ALFF in areas of Left posterior cerebellar lobe,left fusiform gyrus,bilateral temporal lobe,left occipital lobe,left splenium of corpus callosum,left anterior cuneate lobe,right parietal lobe and right inferior parietal lobule,the difference was statistically significant(t=2.10,P<0.05).No ALFF increased areas was found in this study.4 There were negative correlations between AVLT delayed memory and ALFF values of the right temporal lobe,right parahippocampal gyrus and left superior frontal gyrus(r=?0.96,r=?0.91,P<0.05).Negative correlation was found between the AVLT recognition scores and the ALFF values of the right parietal lobe,right inferior parietal lobe(r=?0.94,P<0.05).Conclusions 1 Patients with VCIND have extensive cognitive and overall memory types impairment except naming and orientation.2 In patients with VCIND was found abnormal neuronal activity increased,especially in the temporal lobe,inferior parietal lobule and anterior cuneate lobe which are closely related to cognitive function.3 Memory function decline of VCIND patients is related to the spontaneous activity in multiple brain areas,including right temporal lobe,right parahippocampal gyrus,left superior frontal gyrus,right parietal lobe,right inferior parietal lobule.