The Relationship Between Thrombin Activatable Fibrinolysis Inhibitor And Stroke: A Case-control Study

Background: Stroke is the second leading cause of death and is the most important cause of disability in the world.Compared to other similar surveys,C hina has the highest incidence and mortality rate of stroke.Because of its anti-fibrinolytic function,thrombin-activatable fibrinolysis inhibitor(TAFI)is believed to be associated with an increased risk of several cardiovascular events such as ischemic stroke.Thus,we performed this case-control study to explore the relationship between plasma TAFI levels and stroke in a C hinese population.Methods : Our population-based case-control study contained 217 stroke patients and 218 healthy controls.The TAFI level was measured by immune turbidimetry.Univariate and multivariate logistic regression analyses were used to analyze the association between different TAFI levels and stroke and its subtypes.Restricted cubic spline(RCS)combined with logistic regression analysis were used to explore the dose-response relationship between TAFI levels and stroke.Results: The TAFI levels of cases were much higher than in the control group(p=0.038)and this difference persisted even after adjustment(OR=2.2).In the elderly(aged over 60)and female subgroups,the plasma TAFI levels in stroke patients were higher than those in controls,and the results were also noted in ischemic stroke.The dose-response curve showed that,as a whole,with the increase of TAFI levels,the relative risk of stroke first increased and then decreased(p=0.0127).Similarly,in general,with the increase of TAFI levels,the curve showed that the relative risk of ischemic stroke first increased and then decreased(p=0.0110).Conclusions: There was a definite correlation between plasma TAFI levels and stroke in this Chinese population,and with the increase of TAFI levels,the relative risk of stroke or ischemic stroke first increased and then decreased.