| Objective: To compare and evaluate the efficacy and safety of Abiraterone and Docetaxel in the treatment of castration resistant prostate cancer.Methods: The clinical data of 46 patients with castration-resistant prostate cancer who were admitted to the First Affiliated Hospital of China Medical University from June 2014 to September 2016 were retrospectively analyzed and divided into treatment group and control group.The treatment group was treated with abiraterone(1000mg,once daily)and prednisone(5 mg twice daily),and the treatment was given with abiraterone till the disease progressed.replace other forms of treatment,a total of 23;The control group was given docetaxel(75 mg / m2 surface area once every 3 weeks)plus prednisone(5 mg twice daily)treatment,with docetaxel until the disease progressed,replace other forms of treatment,a total of 23.Patients in each group were followed up for discontinuation of treatment with abiraterone and docetaxel,with discontinuation of disease progression,and discontinuation of follow-up at 12 months for those patients who had a significant response to abiraterone and docetaxel.Observe the progress of the disease in each treatment group within one year and the adverse reactions occurred in the course of treatment,and make statistical analysis.Results: Survival rate was significantly higher in the treatment group than in the control group within 1 years(P=0.015).The incidence of neutropenia and alopecia in the control group was significantly higher than that in the treatment group(P<0.05);The two group in nausea and vomiting and abnormal liver function occurred without significant difference.The incidence of total adverse reactions in the treatment group was 34.8% lower than that of the control group(82.6%),and the difference was statistically significant(P < 0.05).Conclusion:In the treatment of castration-resistant prostate cancer,abiraterone more docetaxel can better inhibit the progress of prostate cancer,prolong the progression-free survival,and the higher incidence of docetaxel adverse reactions,abortion Dragon side reaction is small,well tolerated,to the advanced prostate cancer patients brought the gospel,is an effective means of treatment of castration resistant prostate cancer. |
PDF Full Text Request