Analysis Of Risk Factors And Prevention Of Contrast-induced Nephropathy In Patients Undergoing Coronary Angiography Or Percutaneous Coronary Intervention

Objective : To observe the incidence of contrast-induced nephropathy in patients undergoing coronary angiography or percutaneous coronary intervention,and to explore the risk factors for its occurrence.Methods : A total of 573 patients undergoing CAG or PCI in recent two years were retrospectively analyzed.The changes of serum creatinine and estimated glomerular filtration rate before and after surgery were observed,in the same time to calculate the incidence of CIN.The patients were divided into CIN group and non-CIN group in order to compare the clinical features and discuss the risk factors and preventive measures.Results:CIN occurred in 41 of 573 patients,and the incidence was 7.16%.The factors of age,low density lipoprotein-C,D-Dimer,the proportion of acute myocardial infarction and intra-aortic balloon pump during operation of CIN group were higher than that of non-CIN group,and the factors of serum albumin and free triiodothyronine were lower than that of non-CIN group.The difference was statistically significant(P<0.05).The results of Logistic regression analysis showed that: AMI and intraoperative IABP are the independent risk factors of CIN.In addition,the analysis of preoperative medication demonstrates: preoperative hydration consumption and the proportion of statin use in patients with advanced age and basic renal insufficiency was significantly increased.preoperative hydration consumption in patients with diabetes mellitus was significantly increased and the difference was statistically significant(P <0.05).Conclusion:1.AMI and IABP during operation are independent risk factors for CIN to the patients undergoing CAG or PCI.2.The prevention measures are taked such as hydration and statin can effectively decrease the occurrence of CIN.