MTOR Pathway In Systemic Lupus Erythematosus:an Update

Systemic Lupus Erythematosus(SLE)is a multi-system disease with underlying immune cell dysfunction and producing of autoantibodies.Although the etiology of SLE is only partly known,recent studies have found that mammalian target of rapamycin(m TOR)was a ubiquitous serine/threonine kinase,which played pivotal roles in regulating differentiation of immune cells,autophagy,cytokines excretion as well as oxidative stress and contributed to the pathogenesis of SLE as well.In this article,we review what is currently known in the role of m TOR signaling in SLE,and the investigations aimed at possibilities of m TOR-targeted therapeutic intervention in the disease.