Populational Dose And Health Risk Assessment On Polycyclic Aromatic Hydrocarbons Based On PBPK Model

In order to explore the exposure dose and the health risk of polycyclic aromatic hydrocarbons?PAHs?of common residents in typical urban areas and in barbecue scene,based on the collected and analysed environmental PAHs data,the daily intake of benzo[a]pyrene equivalent doses in urban areas and in barbecue scence of adult men,adult women,children and occupational populations were calculated.The incremental lifetime cancer risk?ILCR?and non-carcinogenic risk of the population were calculated.A self-made PBPK model was used to simulate the internal dose temporal changes and total accumulations of pyrene of the target population.The main conclusions are as follows:?1?the estimated daily dose of benzo[a]pyrene equivalent of urban male residents varys from 0.8 to 19.9 ng·d^-1·kg^-1,and the population cancer risk is within accpectable range.No non-cancer risk is found;?2?the estimated daily intake of benzo[a]pyrene equivalent doses for men,women,children and occupational populations was 1.02 ng·d^-1·kg^-1,1.17 ng·d^-1·kg^-1,1.43 ng·d^-1·kg^-1,2.74 ng·d^-1·kg^-1.The lifetime cancer risk ranged from 9.9×10^-7 to 7.1×10^-6,which is acceptable.Dietary and inhalation route contribute most for common and occupational people,respectively;?3?the tissues maximum concentration of pyrene after barbecue exposure of common people are liver(6.52⁸.67 ng·L^-1),kidney(0.97¹.12 ng·L^-1),venous blood(0.71⁰.94ng·L^-1),skin(0.64⁰.75 ng·L^-1),fat(0.64⁰.75 ng·L^-1).And the tissues maximum concentration of pyrene to occupational people are fat(2.97 ng·L^-1)>skin(1.14 ng·L^-1)or kidney(1.14 ng·L^-1)>liver(0.57 ng·L^-1),venous blood(0.17 ng·L^-1);the total pyrene accumulative amounts of occupational people is 4 to 8 times of that of common people.