The Relationship Between Th17/Treg Cell Related Inflammatory Factors And Plasma Cell Mastitis

Objectives: This research is based on the levels of Th17 and Treg cell related factors in peripheral blood of patients with plasma cell mastitis,to understand the role of IL-17,IL-10 and TGF-beta 1 in the development of plasma cell mastitis and to investigate existence of Th17/Treg cell imbalance in patients with plasma cell mastitis.Methods: 43 cases of plasma cell mastitis were selected from the Affiliated Hospital of Hebei University from September,2015 to September,2017.At the same time,20 healthy women in the physical examination center of our hospital were randomly selected as the control group.The levels of IL-17,IL-10 and TGF-beta 1 were measured in plasma blood samples,by enzyme-linked immunosorbent assay(ELISA double antibody sandwich method).Result: 1.In plasma cell mastitis group,compared with healthy control group,the plasma level of IL-17 significantly higher than that in healthy controls(P < 0.05),and the plasma levels of IL-10 and TGF-beta 1 were significantly lower than those in healthy controls(P <0.05);2.In the plasma cell mastitis in different clinical stages,IL-17 in the acute phase group levels were compared with subacute group and chronic group,the differences were statistically significant(P < 0.05),IL-10,TGF-beta 1 in plasma cell mastitis in different clinical stages were not statistically significant(P > 0.05);3.In the plasma cell mastitis in different clinical types of IL-17 in the abscess type level of the group were compared with tumor type group,fistula type group,the differences were statistically significant(P < 0.05),IL-10,TGF-beta 1 in plasma cell mastitis in different clinical types,there were no significant differences(P > 0.05).Conclusions: 1.The level of IL-17 is high in plasma cell mastitis patients.IL-10 and TGF-beta 1 show a low level,suggesting that the three may play an important role in the development of plasma cell mastitis.2.The level of IL-17 in patients with acute stage and abscess type is significantly higher than that in other groups.It suggests that IL-17 may be an important factor of acute onset of plasma cell mastitis and abscess formation.3.There is a Th17/Treg cell imbalance in the patients with plasma cell mastitis,which provides a theoretical basis for the pathogenesis and immunotherapy of plasma cell mastitis.