The Clinical Observation On The Safety Of Lower Oxygen Administration During The Maintenance Of General Anesthesia In Children

Objective:To explore the safety of lower oxygen administration during the maintenance of general anesthesia in children.Method:The study was approved by the hospital ethics committee,informed the guardian of children and signed the informed consent for 75children accepted selective laparoscopic surgery in general anesthesia.They were scheduled and divided into 3 groups used a random number table:Group C₄₀?FiO₂=40%?,Group C₃₀?FiO₂=30%?and Group C₂₂?FiO₂=22%?.The time before anesthesia induction was T₁,the time when stoped the peritoneoscope was T₂,recorded the SpO₂,HR and rSO₂ between T₁ and T₂.Extracted the radial artery blood for arterial blood gas analysis atT₂,recorded the PaO₂,PaCO₂,and then calculated the OI,PA-aO₂,RI and Pa O₂/PAO₂,and recorded the time of extubation and the stay time in the PACU and the postoperative nausea and vomiting,and surgical site infection.When SpO₂<94%or rSO₂ decreased by20%,or intraoperative blood loss exceeded by 20%of blood volume,excluded the case.Results:During the maintenance,there were 2 cases excluded in Group C₂₂,and no case was excluded in either group C₄₀0 or C₃₀,there was no significant difference?P>0.05?.There was significant difference in PaO₂,PAO₂,PA-aO₂,RI,PaO₂/PAO₂ at T₂?P<0.05?,there was no significant difference in PaCO₂ and OI at T₂?P>0.05?.There was no significant difference in time of extubation and the stay time in the PACU and the postoperative nausea and vomiting and surgical site infection?P>0.05?.Conclusion:On the premise of clinically monitoring and appropriate ventilation model,that the children with normal lung function inhale lower concentration of oxygen is safety,the oxygen concentration can be set from22%to 40%.With the increase of oxygen concentration,the lung gas exchange function may be injured,in a dose-dependent manner.The lower oxygen concentration will not increase postoperative nausea and vomiting and surgical site infection.