Effect Of Blood Calcium Concentration On Vascular Calcification In Peritoneal Dialysis Patients

Objective:To observe the changes of serum calcium and the severity of abdominal aortic calcification in patients with regular CAPD,the correlation between different calcium concentrations and the degree of abdominal aortic calcification was analyzed to understand the effect of serum calcium concentration on vascular calcification.Methods:A total of one hundred forty-two cases of maintenance peritoneal dialysis patients were enrolled in our hospital,collected clinical data and laboratory indicators,and assessed the status of abdominal aortic calcification using lateral abdominal plain films,respectively,according to the patient’s serum calcium levels and AACs scores,cross-sectional the relationship between serum calcium and vascular calcification in selected patients was analyzed.Results:1.A total of the one hundred forty-two patients,the incidence of hypercalcemia was 16.90%,and the incidence of vascular calcification(AACs≥ 1)was 44.37%.According to the KDIGO guidelines,patients were divided into low calcium group(Ca<2.10 mmol/L),normal calcium group(2.10mmol/L≤Ca≤2.50 mmol/L),and high calcium group(Ca>2.50 mmol/L).The dialysis age,residual kidney Kt/V,blood urea nitrogen,and calcium-phosphorus product were significantly different in the high-calcium group(P<0.05).With the increase of serum calcium levels,the AACs were statistically different(P<0.05).2.According to the AACs group,there were 79 cases(57.25%)without calcification,30 cases(21.74%)with mild calcification,24 cases(17.39%)with moderate calcification,and 9 cases(6.34%)with severe calcification;Blood calcium and levels increased progressively with statistical differencesbetween groups(P<0.05).3.According to whether the patient took calcium group,there was no significant difference in gender,AACs,dialysis age,serum calcium,phosphorus,calcium and phosphorus product between the two groups.4.Correlation analysis: AAC was positively correlated with age,dialysis age,serum calcium,and was not related to serum phosphorus,calcium-phosphorus product;serum calcium was positively correlated with dialysis age,calcification integral,calcium-phosphorus product,and negative with whole-parathyroid hormone.Related.Multiple regression analysis: Age,age of dialysis,and serum calcium were independent risk factors for the severity of AAC in PD patients.Conclusion:1.Long-term PD patients age,dialysis age,serum calcium concentration and AAC were positively correlated.2.Hypercalcemia is an independent risk factor for the severity of AAC in PD patients.