Effect Of Continuous Positive Airway Pressure In Aminotransferase On OSA With Nonalcoholic Fatty Liver Disease Patients:A Meta-Analysis

Objective:To review the evidence for the effect of continuous positive airway pressure on obstructive sleep apnea with nonalcoholic fatty liver disease patients,and assess wether CPAP treatmnet can reduce serum aminotransferase.To explore whether CPAP therapy can improve liver pathology in patients with OSA and NAFLD,and provide a new idea for NAFLD treatment.Method:We search databases in Pubmed,Embase,Cochrane Library,Web of science,CBM Database,WANFANG,CNKI for trials comparing serum aminotransferase and BMI before or after CPAP.We also compare CPAP treatment group with sham CPAP group in transaminase from RCTs.All data were analyzed using Review Manager 5.2.Results:1.Seven studies included 180 participants.The Meta-analysis showed that:1)CPAP treatment depressed the aspartate aminotransferase of nonalcoholic fatty liver disease patients with OSA.2)Less than 3 months of CPAP treatment cannot depress the alanine aminotransferase,but 3 months or more than 3months of CPAP treatment depressed the alanine aminotransferase.So the duration of CPAP treatment may be a key factor in depressing the liver enzyme.2.Five studies included 116 participants.There was no significant change in BMI in patients with nonalcoholic fatty liver disease before and after CPAP.3.Three RCTs included 158 participants.The Meta-analysis showed that:There was no significant difference in aminotransferase between the CPAP treatment group and the sham CPAP group.