The Safety And Efficacy Of Tace Combined With Tips In Patients With Liver Cancer And Portal Hypertension

Objective: Retrospectively evaluate the safety and efficacy of TACE(transcatheter arterial chemoembolization)combined with TIPS(transjugular intrahepatic portosystemic shunt)in patients with primary liver cancer complicated with cirrhosis and portal hypertension.Methods: Collected in our hospital in January 2011 to January 2015 due to liver cancer with cirrhosis portal hypertension who underwent TACE combined with TIPS in 22 cases;Twenty-eight patients with hepatocellular carcinoma complicated with cirrhosis treated with TACE without TIPS were selected as the control group.The curative effect and prognosis of the two groups were observed.Results: The success rate of TIPS was 100%(22/22),the postoperative portal pressure was 38.4 � 7.6 cm H2 O,and the postoperative portal pressure was 28.4 � 7.7cm H2 O,the difference was statistically significant(p<0.01);the portal vein diameter was 16.2 � 2.5mm,postoperative portal vein diameter of 13.3 � 1.8mm,the difference was statistically significant(p <0.01).1 year postoperative patency rate of 95%,two years patrol rate of 90%.The rate of rebleeding in the control group was 60.7% and 78.5% respectively,compared with 9.1% and 13.6% in theTIPS group,respectively(P<0.05).The difference was statistically significant.The cumulative survival rate was 81% in the TIPS group and68% in the two years.The median survival time was 53 months.The cumulative survival rate of the control group was 78% in one year and the cumulative survival rate was 15% The median survival time was 17 months,P <0.05,the difference was statistically significant.Conclusions Hepatic carcinoma with portal hypertension treated combined with conventional TIPS can be safe and effective control tumor development,reduce and even eliminate the portal hypertension syndrome,and improve the life quality and survival rate.