Synthesis Of Furan And Its Derivatives From ?-Haloketones And ?-Dicaronoyl Compounds

Derivatives containing a furan ring are widely present in many natural products and organic synthesis products,because the furan ring-containing compound has a variety of biological activities such as anti-cancer,anti-bacterial activity,anti-viral,anti-allergy,anti-HIV activity and the like.Its synthesis research has always been a research hotspot in the field of chemical synthesis.Among the most classical methods are the Feist-Bénary reaction and the Paal-Knorr furan synthesis reaction.This research project mainly synthesizes para-substituted furan derivatives using ?-haloketones and ?-dicarbonyl compounds as substrates.Researcs in the dissertation mainly involves two aspects of work:1)A series of para-carbonyl compounds and 2,3-dihydrofuran compounds were synthesized from ?-haloketones and ?-dicarbonyl compounds.2)Synthesis of para-substituted furan derivatives from para-carbonyl compounds.Titanium tetrachloride was firstly used as a dehydrating agent in this reaction.Merits of the synthetic method include: moderate reaction conditions,simple operating process,and high yields.