The Correlative Analysis Between The Serum E₂ Of 397 Early Threatened Abortion Females With The Result Of Miscarriage Prevention And TCM Syndrome

Objective:1.To explore the value of E₂ monitoring to determine the outcome of early threatened abortion.This is to provide data support for the clinical application of estrogen in the process of early threatened abortion and in vitro embryo transfer,and to provide a reference for clinical follow-up and improve the rate of pregnancy and prevent blindness from giving birth to unnecessary care for patients and families.2.To reveal the distribution of TCM syndrome of early threatened abortion and further analyze serum levels of E₂ among different TCM syndrome.Method:The data of patients with early threatened abortion were collected from June2014 to June 2016 at the Department of Gynecology Hospital of Chengdu University of Traditional Chinese Medicine in June,and 397 cases were selected according to the inclusion,elimination and elimination criteria.The end of the round was divided into296 cases of the successful group,101 cases of the failure group.The age,menstrual status,history of ovarian surgery,history of maternal pregnancy,E₂ level of 4 to 10weeks of pregnancy,gestational sac,embryo,fetal heart,TCM syndromes were collected from 6 to 10 weeks.The valid data entered into Excel,using SPSS19.0statistical software for statistical analysis of data.Results:1.397 cases of early threatened abortion patients,the successful group of 296cases,accounting for 74.56%,101 cases of abnormal bleeding group accounted for25.44%.2.397 cases of early pregnancy,rate of abortion rise gradually after age 35.The older failure tocolysis group was significantly higher than the proportion of successful tocolysis group（P<0.05）.3.397 cases of early threatened abortion patients,with spontaneous abortion,abortion increased the number of patients with the risk of failure to increase（P<0.05）.Previous gravidity,parity,drug flow,abortion,premature birth,the number of patients with ectopic pregnancy were no significant effect（P>0.05）for tocolysis outcomes.4.397 cases of early threatened abortion patients,patients with successful tocolysis group serum estradiol values at 5¹0 gestational weeks were significantly higher than that of failure tocolysis group（P<0.05）;successful tocolysis group serum E₂ increases with the increase of gestational age（P<0.05）,while the failure tocolysis group serum E₂ with the gestational weeks growth fluctuation,the decrease and increase were not significant,compared with the previous increase of gestational age were not statistically significant（P>0.05）.5.At 4¹0 gestational weeks,estradiol to determine the threshold of pregnancy outcome for 596.365pg/ml,the maximum Youden index was 0.603752,the sensitivity was 91.02%,specificity was 69.35%,the positive predictive value was 92.15%,the negative predictive value was 66.15%,the positive likelihood ratio was 97.01%,negative likelihood ratio was 12.95%,the rate of misdiagnosis 8.98%,the misdiagnosis rate was 30.65%.6.397 cases of early threatened abortion patients,successful tocolysis group and the average diameter of the gestational sac failure tocolysis group showed an increasing trend,but at 6¹0 weeks gestational sac failure tocolysis group average diameters were less than successful tocolysis group（P<0.05）,and the growth of plumule length and gestational age is positively related to,or even tenth weeks germ length a shortened change per week of pregnancy was not statistically significant（P<0.05）;fetal heart rate is also visible are low,sixth weeks for 2.5%（1 cases）,the rate of visible tenth weeks cardiotocography is 19%.7.397 cases of early threatened abortion patients,kidney deficiency had the highest frequency of 75.06%,together for the first class of two;deficiency of spleen and kidney were clustered into second groups,kidney deficiency and blood stasis,blood heat syndrome and blood deficiency syndrome into third categories.8.Kidney deficiency syndrome and blood heat syndrome,kidney deficiency syndrome and spleen and kidney deficiency syndrome,blood heat syndrome and spleen and kidney deficiency syndrome,blood heat syndrome and spleen and kidney deficiency syndrome were not statistically significant.Compared with kidney deficiency and blood stasis syndrome,there was significant difference between the two groups（P<0.05）.Indicating that patients with kidney deficiency type of blood deficiency type,spleen and kidney deficiency type of pregnancy failure rate is high.9.397 patients with early threatened abortion,kidney deficiency,blood heat syndrome,deficiency of spleen and kidney two,no significant differences in serum estradiol levels between kidney deficiency and blood stasis syndrome（P>0.05）.Conclusion:1.Age is one of the risk factors of pregnancy outcome,pregnancy loss rate increased significantly more than 35 year old woman.2.The patient gravidity,parity,medical abortion,abortion,premature birth,number of ectopic pregnancy outcome of tocolysis effect is not obvious,but with the spontaneous abortion,the number of abortions increased,the risk of failure of patients with anorexia increased.3.Serum estradiol level is an important index to predict the outcome of early pregnancy,and to guide the dosage of hormone.E₂ concentration is high and its growth is stable with the increase of gestational age.4.Estradiol is greater than or equal to 596.365pg/ml is indicative of a good outcome of pregnancy,the success probability.5.Type-B ultrasonic examination showed that the gestational sac increased gradually with the increase of gestational age.The results showed that the pregnancy outcome was good.The high risk patients with fetal heart at 8¹0 weeks of gestation were still need to follow up closely.6.Patients with early threatened abortion（abdominal pain in pregnancy,fetal leakage,fetal irritability）syndrome distribution of kidney deficiency syndrome,TCM syndrome type of Early Threatened Abortion miscarriage outcome has a certain effect,the deficiency of kidney and blood stasis type patients with kidney deficiency,spleen and kidney deficiency two patients with pregnancy failure rate is high.7.There was no significant correlation between TCM syndrome and serum estradiol levels.