| PurposeTo observe the clinical effect on chronic nonspecific low back pain(CNLBP)with cold dampness syndrome by applying the method of Jianpi Wenyang Lishui,explore its possible therapeutic mechanism and provide references for this disease.Method72 patients with cold-dampness type chronic nonspecific low back pain were randomly divided into experimental group and control group,experimental group was treated with basic treatment and "Jianpi Wenyang Lishui Decoction" orally,36 cases were observed;the control group was treated with basic treatment and Celecoxib Capsules orally,36 cases were observed.The score assessment is being divided into four different stages before treatment,one-week after treatment,two-week after treatment and one-month after the end of treatment.At each stage of measurements,it will record McGill score and ODI score for each patient.The results were statistically analyzed by SPASS21.0 software,and the differences between the two groups were compared.Results1.There was no significant difference between two groups in gender,age,duration of disease,McGill and ODI scores before treatment(P>0.05).2.By applying independent sample t-test,it can be found that the McGill score has statistically significant at one-week after treatment,two-week after treatment and one-month after the end of treatment(P<0.05).The control group has better improvement than experimental group at one-week after treatment(10.0<13.37).Aftertwo weeks of treatment,the experimental group has better improvement than control group(6.93<9.63).One-month after the end of treatment t,the experimental group has better improvement than control group(6.63<11.07).By applying Tukey HSD,it can be found that the McGill score at one-week after treatment,two-week after treatment and one-month after the end of treatment compared with the stage before treatment has significant difference(P<0.05).The control group has better assessment result than experimental group at one-week after treatment(|-7.100|>|-4.700|).But the experimental group has better results at two-week after treatment and one-month after the end of treatment(|-11.133|>|-7.467|,|-11.433|>|-6.033|).The score one-month after the end of treatment compared with two-week after treatment assessment,it shows the score of western medicine group was positive,the score was increased,the condition was repeated;the traditional Chinese medicine group was negative,indicating that the score continued to decline,the condition was stable without repeated.3.By applying independent sample t-test,it can be found that the ODI score has no statistically significant at two-week after treatment(P>0.05).At one-month after the end of treatment,it can be found that there is significant different between two groups(P<0.05).The experimental group has much better improve than control group(10.90< 18.92).By applying Tukey HSD,it can be found that the ODI score at two-week after treatment and one-month after the end of treatment compared with the stage before treatment has significant difference(P<0.05).The experimental group has better results at two-week after treatment and one-month after the end of treatment(|-12.768|>|-10.530|;|-17.708|>|-9.197|).The score one-month after the end of treatment compared with two-week after treatment assessment,it shows the score of western medicine group was positive,the score was increased,the condition was repeated;the traditional Chinese medicine group was negative,indicating that the score continued to decline,the condition was stable without repeated.4.There was no significant difference in clinical efficacy after the whole therapybetween two groups(P>0.05).However,the overall improvement rate and cure rate of the Traditional Chinese Medicine group were better than those in the western medicine group(83.33%>80.00%;13.3%>6.67%).5.The incidence of adverse events between the two groups was statistically significant(P < 0.05).The adverse reactions of Traditional Chinese Medicine group were less than those patients in western medicine group,and the safety was better than those patients in western medicine group.Conclusion1."Jianpi Wenyang lishui party" and Celecoxib Capsules can reduce the clinical symptoms and dysfunction in patients with cold-dampness type chronic nonspecific low back pain,Celecoxib Capsules rapid onset,but the long-term efficacy was significantly decreased;"Jianpi Wenyang Lishui party " is relatively slow,but the long-term effect is stable.2.The method of Jianpi Wenyang Lishui for the treatment of patients with cold-dampness type chronic nonspecific low back pain,not only can effectively reduce the clinical symptoms,but also can relieve their dysfunction,compare with the conventional western medicine,the clinical effect t is stable,not easy to be repeated,and has the higher safety. |
