| Objective:1.Analysis of the retinal nerve fiber layer(RNFL)thickness of the patients with chronic obstructive pulmonary disease(COPD);2.To investigate the correlation between the retinal nerve fiber layer thicknes s(RNFL)and the severity of COPD in patients with chronic obstructive pulmona ry disease(COPD);3.It provides the basis for the early diagnosis and treatment of glaucoma in COPD patients,so as to reduce the blindness rate of glaucoma.Methods:A total of 30 COPD patients(all have smoking history and history of hypert ension)were diagnosed by lung function test in Department of respiration from N ovember 2015 to April-2016.Among them,17 cases were mild,11 were modera te,2 were severe,and 0 were very severe.30 patients with hypertension matched by age,sex and body mass index(BMI)were used as the control group(all ha ve smoking history).Following the exclusion of subjects:(1)a history of eye dis ease,glaucoma and other ocular trauma or surgery;(2)the diopter of >-6.00D;(3)the application of hormone for a long time;(4)alcoholics;(5)patients with inte rstitial lung disease,bronchial asthma,cerebrovascular disease,diabetes;(6)sufferi ng from mental diseases and other diseases which affect the inspection of the OC T.All subjects underwent blood pressure measurement,pulmonary function test an d detailed eye examination,including eyesight,intraocular pressure,slit lamp examination,optometry,fundus and perimetry.To meet the requirements of the experi mental group and the control group,the unified measurement of the subjects of ri ght,the thickness of RNFL using Topcon3 D OCT.2000 measurement of average t hickness of RNFL and superior,inferior,nasal and temporal side of 4 quadrants,t he application of statistical analysis of the thickness of RNFL COPD group and t he control group had no difference.Results:1.Patients in the study group was 56~86 years old,the average age was 71.33 ±8.89 years old,the gender ratio of 19:11,body mass index(BMI)for 19.45 ~ 25.34Kg/m~2,the average body mass index was 23.17 ± 1.53,blood pressure is 153~ 178/72 ~ 112 mmHg,the average blood pressure was 165.63 ±7.90/88.13 ± 2.05 mmHg.The control group was 51~88 years old,the average age was 68.10±9.91 years old,the gender ratio of 17:13,body mass index(BMI)for 18.33 ~ 24.77Kg/m~2,the average body mass index was 22.26 ± 1.83,blood pressure is 149~ 180/76 ~ 127 mmHg,the average blood pressure was 163.53 ± 1.80/ 88.13± 11.21 mm Hg.There was no significant difference in age,sex,body mass index and blood pressure between the study group and the control group(P>0.05).2.At the initial diagnosis,the percentage of estimated FEV1 in the COPD group and the control group was 66.10%±2.27%,and 103.68%±1.98%,and the differ ence was statistically significant(t=14.274,P=0.00).3.In the study group,the superior RNFL thickness was 71-159?m,the average v alue of the superior RNFL thickness is 129.20±20.25?m,the inferior RNFL thick ness was 71~153?m,the average value of the inferior RNFL thickness is 121.37±20.20?m,the nasal RNFL thickness was 57~115?m,the average value of the na sal RNFL thickness is 78.70±13.46?m,the temporal RNFL thickness was 42~138?m,the average value of the temporal RNFL thickness is 86.30±20.69?m,the av erage RNFL thickness of study group was 104.90±11.68?m.In the control group,the superior RNFL thickness was 93-161?m,the average value of the superior R NFL thickness is 131.80±16.27?m,the inferior RNFL thickness was 102~159?m,the average value of the inferior RNFL thickness is 130.63±12.95?m,the nasal RNFL thickness was 60~131?m,the average value of the nasal RNFL thickness is80.50±17.23?m,the temporal RNFL thickness was 51~101?m,the average value of the temporal RNFL thickness is 86.30±20.69?m,the average RNFL thickness of the contronl group was 106.00±8.69?m.The superior,the nasal side and the average RNFL thickness of the COPD group were thinner than those of the cont rol group,while the inferior RNFL thickness of the COPD group was significantl y thinner than that of the control group(t=2.063,p=0.048).4.Pearson test showed that there was no significant correlation between the thick ness of RNFL under COPD and the percentage of estimated FEV1(r=-0.015,p=0.936).Conclusion:1.The superior,inferior,nasal and average RNFL thickness of COPD patients wa s thinner than that of the control group,and the inferior RNFL thickness of the COPD group was significantly thinner than that of the control group,indicating th at the possibility of visual field defection in the patients was higher than that in the normal controls.2.The degree of thinning of RNFL in COPD patients was not significantly correla ted with the severity of COPD. |
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