| Objective:To observe the relationship between serum high mobility group protein?HMGB1?and procalcitonin?PCT?levels and severity of disease in patients with acute pancreatitis?AP?,and analyze the relationship between HMGB1 and PCT in the course of AP To investigate the clinical assessment and diagnostic significance of serum HMGB1 and PCT levels in patients with AP.Methods:The clinical data of 45 AP patients admitted to the Second Clinical Hospital of Shanxi Medical University from March 2017 to December 2017 were collected.All patients were classified as mild acute pancreatitis MAP according to the"Guide to the diagnosis and treatment of acute pancreatitis in China 2013"[1].Group,moderately severe acute pancreatitis MASP group and severe acute pancreatitis SAP group.The fasting peripheral venous blood was taken from each patient after admission to the hospital and serum HMGB1 and PCT levels were determined.In addition,45 healthy volunteers were selected as the control group at the same time in our physical examination center to compare the difference between the experimental group and the control group.The serum HMGB1,PCT and Ranson scores,APACHEII scores,and BISAP scores of the three groups were analyzed.And the relevance of MCTSI scores,to explore the monitoring of serum HMGB1,PCT in the diagnosis of patients with AP clinical evaluation and diagnostic value.Results:The 24 h fasting serum HMGB1 and PCT levels in experimental patients were significantly different between the groups and the control group?P<0.05?.There was a statistically significant difference between each group?P<0.05?,and serum levels of HMGB1 and PCT increased with increasing severity of disease in patients with AP;serum HMGB1,PCT levels in patients with mild pancreatitis?MAP?There was no correlation with the four scores;in the moderately severe acute pancreatitis?MASP?group,serum HMGB1 and PCT levels had no significant correlation with the MCTSI score,but had correlations with the other three scores.The difference was statistically significant;Severe pancreatitis?SAP?group,serum HMGB1,PCT levels were significantly positively correlated with the four scores?P<0.05?.In patients with MASP and SAP degrees,serum HMGB1 and patients with incompetent pancreatitis The PCT levels were?25.23±4.45?and?2.23±0.63??g/l,which were higher than those without uncombined dysfunction?18.96±4.37?and?1.66±0.62??g/l.There was a statistical difference between the two groups?P<0.05?.Serum HMGB1,PCT levels in patients with pancreatic infection were?25.67±4.28?,?2.33±5.88??g/l higher than those without pancreatic infection?20.07±4.92?and?2.97±0.41??g/l.Statistical significance.In severe pancreatitis patients,5 patients died of disease,the serum HMGB1 and PCT levels in patients with death?28.8±3.23?,?2.97±0.41??g/l,significantly higher than the level of patients without death?24.06±4.85?,?2.30±0.25??g/l,with statistical difference?P<0.05?.Conclusion:With the severity of acute pancreatitis aggravate,serum HMGB1 and PCT levels also increased accordingly.In patients with moderate or severe acute pancreatitis,serum HMGB1 and PCT levels can well express the severity of the disease;in mild acute In patients with pancreatitis,serum HMGB1 and PCT levels were not significantly associated with disease severity.The serum HMGB1 and PCT levels can respond well to the prognosis of patients with moderate and severe pancreatitis.Serum HMGB1 and PCT have a certain application prospect as indicators reflecting acute pancreatitis,especially in patients with moderate to severe AP. |
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