Study On Synthesis Of Bioactive Indole Alkaloids

This dissertation includes mainly the following two sections: the biomimetic synthesis of Homofascaplysin C and synthesis of novel benzofuran pyridine spiro compounds.(1)The biomimetic synthesis of Homofascaplysin C:Oceans are unique resources that provide a diverse array of natural products,primarily from invertebrates such as sponges,tunicates,bryozoans,and molluscs,and from marine bacteria and cyanobacteria?Marine organisms produce structurally distinct secondary metabolites,possibly due to factors unique to marine environments such as high salinity and pressure and constant temperature.Fascaplysin originally isolated from a marine sponge Fascaplysinopsis sp.,displays a variety of biological activities,such as selective CDK 4 inhibition.Because of the DNA binding,we choose our research on its analogs,Homofascaplysin C..This section mainly focused on the biomimitic synthesis of Homofascaplysin C,with tryptophan as starting material,and with selective and sequential oxidative cleavage as key steps.(2)Lamellarins are a large family of marine alkaloids with potential anticancer activity that have been isolated from diverse marine organisms,mainly ascidians and sponges.In the process of synthesis of this compounds,we have accidentally got a new type of spiro compound.This part described the structural feature,biologic al activities and the synthetic methods of spiro compounds.At final,we focused on the synthesis of novel benzofuran pyridine spiro compounds and its analogs.