| Objective:The treatment of bronchial asthma with asthma is mild and moderate in the acute stage of bronchial asthma.It is a syndrome of lung spleen and kidney deficiency,and the patients with phlegm and obstructive pulmonary disease,observe clinical curative effect and explore the possible mechanism of action.Methods:(1)Subjects: this study selected 60 patients who met the diagnostic criteria of Chinese and western medicine.Bronchial asthma is mild and moderate in the acute stage of asthma,and the syndrome is the deficiency of the spleen and kidney of the lung,and the phlegm obstructive pulmonary disease.(2)Specific grouping: The patients were randomly assigned and set as a control group and a treatment group,with 30 cases in each group.The control group received budesonide formoterol powder inhaler(specification: 160 μg/4.5 μg/suction)and the treatment group received inhaled budesonide formoterol powder inhaler(specification:160 μg/4.5 μg/suction).(3)Drug Usage: Budesonide Formoterol Powder Inhaler Usage: 1 inhale each morning and evening,gargle after 5 minutes;asthma flat granules Drug composition: Yam 20 g,Atractylodes macrocephala 10 g,Poria 8g,Ephedra 6g,Wood butterfly 10 g,Perilla seed10 g.One day of Chinese medicine,oral administration is divided into two groups sooner or later.(4)Course of treatment: Both courses of treatment are 8 weeks.(5)observation indexes: the patients’ serum il-17 and pdgf-bb were tested by the experimental results,which were compared with the experimental results.(6)During the course of treatment,five visits were conducted during the course of treatment.During the period,if the patient was in progress or in critical condition,he could temporarily use the albuterol aerosol for first aid or hospitalization.Results:(1)clinical efficacy evaluation:(1)clinical efficacy: The total effective rate of the treatment group was 92.6%;control group,the total effective rate was 78.6%,the difference was statistically significant(p<0.01),It is indicated that asthma is better than ICS +LABA in treating asthma.(2)Therapeutic effect of TCM Syndrome: The total effective rate of TCM Syndrome in remedy form was 88.9%,control group was 64.3%,and there was significant difference(p<0.01),Conclusion Asthma Pingji granules combined with ICS+LABA better than traditional Chinese medicine symptoms.(2)Efficacy indicators assessment:(1)TCM Syndrome Score: the two forms Compared no statistical difference before treatment(P> 0.05).After 8 weeks of treatment,the scores of TCM syndromes in the treatment group were significantly lower than those before treatment(P<0.01).Before and after treatment in the control group,TCM syndrome scores did not change significantly(P>0.05).Compared with the control group,the TCM syndrome scores in the treatment group were statistically significant(P <0.01),which showed that the treatment group was significantly better than the control group in improving the TCM syndrome score.(2)ACT score: the two forms Compared no statistical difference before treatment(P>0.05).After 8 weeks of treatment,ACT scores of both groups were higher than before(P<0.01)There was also a statistically significant difference in ACT scores after treatment(P <0.05).The results showed that both the treatment group and the control group could improve the ACT score and effectively control the symptoms of asthma patients.However,the treatment group was more effective than the control group in controlling the patient’s condition.(3)FeNO value: Through the two groups of patients before treatment,the FeNO level after 8 weeks of treatment statistics.There was no significant difference between the two groups before treatment(p>0.05).After 8 weeks of treatment,the difference between the two groups was statistically significant(p<0.01),The difference betweenthe treatment group and the control group was statistically significant(p<0.05)Both the treatment group and the control group can reduce the level of FeNO and improve the airway inflammation.However,ICS+LABA,an asthma agent,reduced FeNO even more significantly.(4)The levels of serum IL-17 and PDGF-BB in the two groups were compared before and after treatment: There was no significant difference between the two forms before treatment(P> 0.05).After treatment,serum IL-17 and PDGF-BB levels were lower in both groups(P <0.01).Compared with the control group,the levels of serum IL-17 and PDGF-BB in the treatment group were lower than those in the control group,the difference was statistically significant(P <0.05).Tip: Both drugs can reduce serum IL-17,PDGF-BB levels,but the treatment group is better than the control group.(3)Adverse reactions:(4)During treatment and follow-up,there was no side effect in the treatment group and the control group.The two groups of drugs are safe and reliable,no obvious side effects.Suitable for long-term treatment of patients(5)safety assessment: side effects appear\nIn the treatment and follow-up period,the two groups of patients taking drugs adverse reactions were observed,no adverse reactions in both groups.After treatment,the treatment group and the control group in the three major routine,liver and kidney function,coagulation routine and other safety indicators compared with before treatment were no significant difference(p>0.05),indicating that the two drugs in patients with various safety indicators Adverse effects,taking both drugs are safe.Conclusion:Both Asthma Capsule and budesonide formoterol powder inhaler can effectively improve the acute exacerbation of bronchial asthma,which are the clinical symptoms of pulmonary spleen and kidney deficiency and phlegm blocking pneumonia,reduce the levels of FeNO,serum IL17 and PDGF-BB level,but asthma Ping Chongji combined with ICS LABA can effectively improve clinical symptoms,relieve airway spasm,control the disease,reduce the level of inflammatory cytokines,it is worth clinical promotion and application. |
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