Enhanced Photothermal Therapy And Studied Mechanism Of Hct116 Cancer By Biomimetic Polypyrrole Nanoparticles And Paclitaxel-hollow Carbon Nanospheres

Cancer is the high incidence of the disease,cancer medicine of paclitaxel(PTX)is widely used particularly ovarian cancer,breast cancer,lung cancer,and so on.But its insoluble in water and have some side effects on the body when using paclitaxel alone to treat cancer.Research shows that the combined use of different therapies is conducive to improve the effectiveness of hct116 therapy.The chemo-photothermal therapy is commonly used in one nanocarrier to provide an excellent synergistic effect for cancer therapy over photothermal therapy(PTT)or chemotherapy alone.Reduces the side effects of paclitaxel and makes it soluble in water.In this study,biocompatible and monodisperse hollow carbon nanospheres(HCNs)were developed as a multifunctional platform for the delivery of Chinese medicine of PTX and PTT of cancer simultaneously.PTX can soluble in water because of HCNs.The mesoporous HCNs have large pore volume and proper channels for loading and release of PTX.Upon near-infrared(NIR)laser illumination,the photothermal mediator of HCNs could effectively convert absorbed light into heat,which triggered rapid release of chemotherapeutic drug from HCNs through dissociating the interactions between PTX and HCNs by heat energy.A large number of tumor cells were significantly destroyed when hct116 cells treated with PTX@HCNs were irradiated,which was mainly attribute to the synergisticresult of HCNs-mediated photothermal damage and cytotoxicity of light-triggered PTX release.The study is an important reference for treating hct116 cancer.Cancer has become a major threat to human death.Photothermal therapy(PTT)has attracted much attention in the field of cancer therapy.In this study,we reported a long-circulation biomimetic photothermal nanoagent.By using a simply nanocoating technology,a biomimetic layer of natural red blood cell(RBC)membranes was camouflaged on the surface of photothermal polypyrrole nanoparticles(PPy@RBC NPs).The erythrocyte-mimicking PPy NPs inherited the immune evasion ability from natural RBC resulting in superior prolonged blood retention time.Additionally,excellent photothermal and photoacoustic imaging functionalities were all retained attributing to PPy NPs cores.To further improve the photothermal outcome,the endothelin A(ETA)receptor antagonist BQ123 was jointly employed to regulate tumor microenvironment.The BQ123 could induce tumor vascular relaxation and increase blood flow perfusion through modulating an ET-1/ETA transduction pathway and blocking the ETA receptor,whereas the vessel perfusion of normal tissues was not altered.Through our well-designed tactic,the concentration of biomimetic PPy NPs in tumor site was significantly improved when administered systematically.The study documented that the antitumor of hct116 efficiency of biomimetic PPy NPs combined with specific antagonist BQ123 was particularly prominent and was superior to biomimetic PPy NPs(P<0.05)and PEGylated PPy NPs with BQ123(P<0.01),showing that the greatly enhanced photothermal treatment could be achieved with low-dose administration ofphotothermal agents.Our findings would provide a promising procedure for other similar enhanced photothermal treatment by blocking ETA receptor to dramatically increase the delivery of biomimetic photothermal nanomaterials.