| Objective: To investigate the short-term efficacy and safety of Calli Spheres? drug-eluting beads in the treatment of medium-later period primary liver cancer.Methods: A total of 65 patients with advanced primary liver cancer were included in the study.Among them,28 patients were treated with DEB-TACE,and 37 patients were treated with conventional transarterial arterial chemoembolization(c TACE).After the intervention,the short-term efficacy of the two groups of patients was evaluated by two criteria,m RECIST solid tumor evaluation criteria and serum alpha-fetoprotein(AFP)changes.In addition,blood laboratory,liver function,renal function,and coagulation function-related laboratory parameters and the incidence of adverse reactions and complications were compared between the two groups before and after interventional treatment.Results: The level of serum AFP in DEB-TACE group was significantly lower than that before surgery at 1 month and 2 months after operation(P<0.05).However,there was no significant difference in serum AFP level between c TACE group and preoperative group(P>0.05).At 2 months after operation,the objective response rate(78.57%)in the DEB-TACE group was significantly higher than that in the c TACE group(54.05%),with a significant difference(P<0.05).There was no significant difference in laboratory indicators between the two groups before surgery(P>0.05).Within 1 week after surgery,serum albumin(ALB),hemoglobin(HGB),platelet(PLB)decreased,prothrombin time(PT),and alanine aminotransferase(ALT)increased in both groups.The difference was statistically significant(P<0.05).The incidence of abdominal pain and bloating in the DEB-TACE group was significantly lower than that in the c TACE group(P<0.05).Conclusion: The short-term efficacy of DEB-TACE in the treatment of medium-later period primary liver cancer is better than c TACE,and the incidence of complications is lower,safe and feasible. |
PDF Full Text Request