| Objective:In this study,To compared the clinical symptoms,scale expression and biochemical indexes about PMDD of liver depression and qi stagnation,and discussed the efficacy and safety of the method in order to improve the quality of life.It also provides a safe,effective and simple method for clinical treatment of PMDD.Methods:In the randomized controlled trial design,60 patients who met the criteria of diagnosis and inclusion were randomly divided into two groups: the treatment group and the control group.In luteal phase,the two groups were all treated with acupoint electric stimulation by Midnight-noon ebb-flow instrument.Different from the control group,the treatment group should be treated with opening acupoint according to the patients’ time to go to see the doctor,the treatment time is 30 minutes,3 times of premenstrual treatment,lasting 3 menstrual cycles.During the course of treatment,collecting symptoms of disease and completing the tabulation of the DRSP,HAMA,STAI,and the BBT,forming the datas about the estradiol,progesterone,Age,course of disease,marriage,education,income,social psychological factors,four diagnoses of TCMetc,were used to establish the database with Microsoft Office Excel,and the data were analyzed by PASS Statistics 20.0.The data were analyzed by t-test method that was significant difference between the two groups(P < 0.05).To explore the clinical efficacy and safety of Midnight-noon ebb-flow in Treating PMDD of liver depression and qi stagnation.Results:1.Data base,including age、course of disease、education、income、marriage、medical history and family history、social and psychological factors etc;the tabulation about DRSP、HAMA、STAI before treatment;the levels of sex hormones include progesterone and estradiol;and diagnose of the liverdepression and qi stagnation.All the data had comparisoned that the results showed the P value was more than 0.05,there was no statistical significance,had comparability.2.About DRSP,The total effective rate of the treatment group(77.0)was higher than the control group(63.3%);the score was significantly lower that through the comparative analysis of the data before treatment、after treatment and during the follow-up period,statistically significant(P<0.01).Comparison of the efficacy between two groups was significant(P<0.05),indicating that the treatment group was better than the control group.3.About HAMA,The total effective rate of the treatment group(83.3%)was higher than the control group(66.7%).the score was significantly lower that through the comparative analysis of the data before treatment、after treatment and during the follow-up period,statistically significant(P<0.01).And comparison of the efficacy between two groups was significant(P<0.05),indicating that the treatment group was better than the control group.4.About STAI,The total effective rate of the treatment group(66.67%)was higher than the control group(60.0%),and the score was significantly lower that through the comparative analysis of the data before treatment、after treatment and during the follow-up period,statistically significant(P<0.01).Comparison of the efficacy between two groups was significant(P>0.05),indicating that there was no significant difference between the two groups.5.The levels of progesterone(P)and estradiol(E2)were compared between the two groups before and after treatment that was no significant difference(P>0.05).Which indicated that there was no significant difference between the two groups in regulating progesterone and estradiol E2.6.Compared with the two groups,the total biphasic cycle rate of BBT before and after treatment was not statistically significant(P>0.05),which indicating there was no significant difference between the two groups on the regulation of BBT.7.In terms of TCM scores,It was found that the scores of TCM syndromes in the treatment group and the control group decreased significantly after treatment(P<0.05),and the difference was statistically significant.Conclusion:(1)The study showed that Najia method of Midnight-noon ebb-flow in Treating PMDD of liver depression and qi stagnation is a safe and effective treatment method.(2)Najia method of Midnight-noon ebb-flow in improving anxiety 、irritability、swollen breasts has a significant effect.(3)Najia method of Midnight-noon ebb-flow in reducing scores were significantly better than the conventional treatment group.(4)The hormone about E2 and P and the level of BBT,the two groups had no significant differently effect.(5)The two groups can decrease TCM syndrome score,effection is significant. |
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