The Relationship Between EGFR Gene Mutations And Clinical Features In Advanced NSCLC

Objective and background:The incidence and mortality of lung cancer are all over the world,especially in developing countries such as China,because of environmental pollution,food safety,especially smokers,the incidence of lung cancer is increasing year by year.The prevention and treatment of lung cancer has become an important hygienic problem.Targeted therapy is effective in the treatment of advanced non small cell carcinoma,because China is still a developing country.It is limited by the level of economic development.It is a problem that clinicians must consider how to more accurately determine the adaptive population of targeted therapy and avoid unnecessary detection costs.In this study,the results of EGFR gene detection in advanced non-small cell lung cancer(non-small cell lung cancer)in our hospital and the clinicopathological features of the detected cases were grouped according to different characteristics to study the relationship between EGFR gene mutation and its various characteristics,so as to further guide the clinical work.Method: The collection of general clinical data(including sex,age smoking history)and diagnostic data such as pathological data(detection site,type,staging)and EGFR gene detection results were collected for EGFR gene detection in the center research room of China uino Japan Hospital Center,Jilin University,March 1,2012.According to IASLC’s Eighth Edition TNM staging,the staging of advanced non-small cell lung cancer is(stage III B,C-IV A,B stage).The research objects were determined according to the inclusion and exclusion criteria.The subjects were divided into eight groups according to the age,sex,the degree of smoking,the size of the primary lung focus,the pathological stage,the pathological type,the type of specimen and the location of the specimen.Statistical analysis was performed with "IBM SPSS21.0" statistical software.The difference between the two groups was P < 0.05,which was statistically significant.Result:Finally,217 subjects were enrolled,including 102 males and 115 females.The age range is between 28-85 years old,with an average age of 61.7 years.Of the 217 samples,96 were EGFR mutations,with a mutation rate of 44.2%.The specific mutation sites were as follows: 43 19 Del loci(44.8%),2 768 I loci(2.1%),45 L858 R loci(46.9%),4 L861 Q mutations(4.2%);T790M and 19 Del with T790 M mutations in 1 cases(1%).The 8 groups were all adapted to the chi square test.The final results were only related to the EGFR gene mutation.95 of the 202 cases of adenocarcinoma were mutated,the mutation rate was 47%(95/202),the mutation rate of the non adenocarcinoma group was 6.7%(1/15),the theoretical frequency was T > 1,and P=0.002 < 0.05.Conclusion: 1.In advanced non-small cell lung cancer,the most common mutations of EGFR gene are 19 Del and 21L858 R.2.In advanced non-small cell lung cancer,the mutation of EGFR gene is associated with pathological type,and the mutation rate is higher in adenocarcinoma.3.There was no significant difference in EGFR gene mutation in advanced non-small cell lung cancer with age,sex,smoking index,primary size of lung,TNM staging,type of specimen and specimen site.4.In clinical work,the most easily obtained specimens can be selected by EGFR gene detection in advanced non-small cell lung cancer.