Research On The Distribution And Correlation Of TCM Syndromes Of Diabetic Peripheral Neuropathy

Objective:In recent years,with the increasing incidence of diabetes,diabetic peripheral neuropathy has become one of the most common complications of diabetes.Diabetic peripheral neuropathy patients are also increasing.Currently,the pathogenesis and etiology of diabetic peripheral neuropathy are still not completely understood.The treatment is mainly based on symptomatic treatment and prevention.The condition of DPN patients is also increasingly complicated,the course is more prolonged.In Chinese medicine,many from the diabetes disease paralysis to treat diabetic peripheral neuropathy and have a more significant effect.A number of studies have shown that the combination of traditional Chinese and Western medicine can effectively improve the clinical symptoms of diabetic peripheral neuropathy,slowing the progression of the disease and improving the quality of life of patients with diabetic peripheral neuropathy have some preventive effect.Therefore,the purpose of this study is to collect the clinical data collected from the collected case information to analyze the distribution of TCM syndromes of diabetic peripheral neuropathy,and its relationship between the index and syndrome type,and then for the future breakthrough in the prevention and treatment of diabetic peripheral neuropathy difficult to delay the progress of the disease and improve the quality of life of patients provide some reference experience.Method:The research is divided into two parts: literature research and clinical research.Literature research from the perspective of traditional Chinese medicine discusses the overview of diabetic peripheral neuropathy,etiology and pathogenesis,dialectical type,and many physicians on diabetic peripheral neuropathy.Summarizes the pathogenesis,diagnosis and treatment of diabetic peripheral neuropathy from the perspective of Western medicine.In the clinical research section,patients with diabetic peripheral neuropathy undergoing endocrinology and hospitalization at the First Affiliated Hospital of Guangzhou University of Chinese Medicine from March 2016 to December 2017 were investigated.Among them,140 patients met the inclusion criteria.140 patients with DPN reference to Treatise on Febrile Diseases,"the first Yin and Yang,the six dialectics" and the Department of Endocrinology clinics norms,typing.To set up the information collection table of diabetic peripheral neuropathy to record the general situation of DPN patients and the information about the four diagnostic information of TCM and related auxiliary examination results.And all the relevant data statistical analysis,summarizes the diabetic peripheral neuropathy in patients with TCM syndrome distribution and the relationship between the relevant indicators.Results: 1.A total of 140 eligible DPN patients were included.In general,in terms of gender,there are 66 males and 74 females,accounting for 47.14% and 52.86% of the total.Age,the maximum age of 85 years,the youngest age of 22 years;of which,60 years of age accounted for 63.57% of patients.Course of disease,diabetes focus on the course of 6-10 years,accounting for 38.57%.The average course of DPN was 4.05±3.73 years.Focus on the distribution within 1-5 years,accounting for 53.57%.BMI statistics show that low-weight patients,standard weight patients,overweight patients accounted for 3.57% of the total number of 61.43% and 35%.In terms of blood glucose,the fasting blood glucose was controlled at 8.90 ± 3.23mmol/l and the glycosylated hemoglobin was controlled at 8.94 ± 1.66%.Among them,glycated hemoglobin in more than 7.5% were 67.86%.In terms of blood lipids,the average total cholesterol was 4.73 ± 1.26mmol/l,the triglyceride was 2.02 ± 2.4mmol/l,the high density lipoprotein was 1.21 ± 0.56mmol/l,and the average low density lipoprotein was 3.09 ± 0.84mmol/l.The symptom distribution of the 140 cases of DPN patients with higher frequency of symptoms were dry mouth and drank(61.43%),limb numbness(53.57%),limb pain(47.14%),dizziness and headache(44.29%).2.According to "six by dialectical" type,the result is: Shaoyin cold and humid Shengshu highest frequency of occurrence,accounting for 35.71% of the total number.Followed by cold and humid block Shaoyang meridian card and cold stagnation Jue Yin meridian card,accounting for 27.86%、17.86%.Other forms accounted for 18.57%.3.Complications and complications:Among 140 patients with DPN,17 cases of diabetic retinopathy.There are 33 cases of diabetic nephropathy and 29 cases of diabetic lower extremity vascular disease.In addition,there were 65 patients with a history of hypertension,58 patients with a history of hyperlipidemia,10 patients with coronary heart disease,and 24 patients with hyperuricemia.Among them,according to the grouping of other diabetic complications,the statistical results showed that the Shaoyin Deficiency Wetness Syndrome Combined Diabetic Nephropathy Group,Diabetic Lower Extremity Vascular Lesion Group and Non-diabetic Nephropathy Group(X2=4.695,p=0.03),Diabetes There was a statistically significant difference in the lower extremity vascular lesions(X2=17.614,p=0.00).At the same time,there was a significant difference between Shaoyin Deficiency Wetness Syndrome and hyperlipidemia group compared with the group without hyperlipidemia(X2 = 7.630,p = 0.006).4.The comparison of each pair of two groups showed that there was no significant difference in the sex ratio of DPN patients with different syndromes,with no statistical significance.There was no significant difference in age between groups(P> 0.05).Among them,Shaoyin Deficiency and Allergy Syndrome group older,with an average age of 61.24 ± 12.79 years.5.In terms of the course of diabetes,cold and dampness blockage of Jue Yin meridian syndrome> Shaoyin deficiency and cold dampness syndrome> other syndromes group> cold dampness block Shaoyang meridian syndrome group.Shaoyin Deficiency and Allergy Syndrome group and cold dampness block Shaoyang meridian syndrome group compared with significant difference(P <0.05).There was also a significant difference between the group of cold yin and stagnation of juein ying meridian and the group of shaoyang yang stagnation of cold dampness(P<0.05).However,there was no significant difference between Shaoyin Shengmai Syndrome Group and the control group(P> 0.05),while there was no significant difference between the other syndrome groups and each group(P> 0.05).6.BMI,Shaoyin Deficiency and Cold-dampness Syndrome> Cold and damp arrest Shaoyang meridian syndrome> other syndrome group> Alpine meningitis meningitis group.There was a significant difference(P <0.01)between Shaoyin Shengmai Shengji group and Shaoyang meridian group in cold and dampness block;And other syndrome groups were also statistically significant(P <0.01).However,there was no significant difference(P> 0.05)between the cold-dampness-blocking Shaoyang meridian syndrome group,the cold-dampness stagnation Jue Yin meridian syndrome group and other syndrome groups.7.Fasting blood glucose among the groups were compared,Shaoyin deficiency cold and dampness syndrome and cold yin stagnation syndrome group,other syndrome groups were significantly different(P <0.05);However,there was a significant difference(P <0.05)between cold-dampness-blocking Shaoyang meridian syndrome group and cold-jelly blocking Jueyinjing meridian group.Glycosylated hemoglobin,the comparison between groups shows that the Shaoyin Deficiency and Cold Shukong Syndrome,cold and humid block Jingyin meridian card group and cold-dampness block Shaoyang meridians group were significantly different(P <0.05),the rest no significant difference(P> 0.05).8.Various types of blood lipid-related indicators,Each group total cholesterol indicators were compared,Shaoyin cold and dampness syndrome group and the rest of the difference between the significant difference was statistically significant(P <0.05);Compared with other syndrome groups,there was a significant difference in cold-shaving Shaoyang meridian group(P <0.05),however,there was no significant difference between the two groups(P> 0.05).There was also a significant difference between the control group and Jueyin meridian group in other groups(P <0.05).In LDL-C,there was a significant difference(P <0.05)between the Jue Yin meridian group and the other groups.Triglyceride and HDL-C both groups,the difference between the groups was not significant(P> 0.05).9.Observe the correlation between the indexes of 140 DPN patients,there was no significant difference in BMI and blood glucose levels(fasting plasma glucose and glycated hemoglobin)between the sexes,but there was a statistically significant distribution of LDL-C in blood lipids(t=2.016,p=0.046<0.05).At the same time,observing the relationship between each index and age,duration of DPN and duration of diabetes,we know that there is a positive correlation between total cholesterol,HDL-C and LDL-C and DPN course,which has statistical significance(p<0.05).There is no significant difference in the rest.Among the correlations between the indicators,there was a positive correlation between fasting blood glucose and glycated hemoglobin,total cholesterol and LDL-C,triglycerides and LDL-C,total cholesterol and glycated hemoglobin,and between LDL-C and glycated hemoglobin.Statistical significance(p<0.05).Conclusion:Among the 140 patients with diabetic peripheral neuropathy,the distribution ratio of TCM syndromes was Shaoyin Deficiency and Cold-dampness Syndrome> Cold-dampness Blocking Shaoyang meridian syndrome> Alpine-cold blocking Jueyin meridian syndrome> other syndromes.The disease duration of diabetes concentrated in 6-10 years.The DPN course is concentrated in 1-5 years.The majority of patients are over 60 years of age.In terms of symptoms,frequent occurrence of more dry mouth and drink,limb numbness,limb pain and dizziness and headache.Among them,the average age of various syndromes to Shaoyin Deficiency cold and wet Sheng card longer.Cold and humid block Jue Yin meridian card,Shaoyin cold and dampness syndrome patients with long duration of diabetes.The majority of obesity is less Yin and cold dampness Sheng card.Alzheimer’s disease in patients with alpine yin and qi and blood glucose control index and LDL-C control is poor,the index is higher than other syndromes.The cold block Shaoyang meridian syndrome patients with poor total cholesterol control.There is a positive correlation between blood lipid level and blood glucose level on the course and development of diabetic peripheral neuropathy.No matter what kind of syndrome DPN,prevention and treatment of complications,strict control of blood glucose and blood lipid is the foundation.