Controlled Study On Treatment Of Damp Heat Stagnation Syndrome Of Rheumatoid Arthritis In Active Stage By Ertu Removing Dampness And Dredging Arthralgia Prescription

ObjectivesThrough the analysis and comparison of the improvement of observation index in damp heat stasis syndrome of active rheumatoid arthritis after treatment,Clinical evaluation of the efficacy and safety of Ertu removing dampness and dredging arthralgia prescription was made in the treatment of damp heat stasis syndrome of active rheumatoid arthritis,so as to provides a reliable basis for further experimental research and clinical application.MethodsIn this study,66 cases in accordance with the inclusion criteria were collected.,and the patients were randomly divided into the test group and the control group.The test group was given the Ertu removing dampness and dredging arthralgia prescription and Leflunomide Tablets.While the control group was given Shirebi granule and Leflunomide Tablets.After 8 weeks,the change of clinical symptoms and signs,TCM syndrome score,laboratory index,DAS28 score and quality of life score beteewn the two groups were recorded,and the effective rate of TCM symptoms test and the evaluation of ACR were evaluated.The above data are analyzed by statistical software SPSS24.0.Results1 Comparison of the baseline of the two groupsthe patient’s sex,age,course,main symptoms and signs(the number of swollen and tender joints,morning stiffness time),TCM symptom score,VAS pain score,DAS28 score,overall assessment of the disease,the quality of life score(HAQ score,PRO score)and laboratory indexes(RF,ESR,CRP)beteewn the two groups showed no significant difference in statistics before therapy,which reveals the two groups are comparable.2 Comparison of the effective rate of TCM symptoms and the evaluation of ACRThe effect of TCM syndrome:The overall effective rate of the test group was 93.5%(29/31),where 6 cases had marked effect(19.4%),23 cases were effective(74.2%)and 2 cases were invalid(6.4%).The overall effective rate of the control group was 81.2%(26/32),where 2 cases had marked effect(6.2%),24 cases were effective(75%)and 6 cases were invalid(18.7%).There was a significant difference between the two groups(P<0.05),so test group is superior to control group.Evaluation of ACR:The test group reaching ACR20 or ACR50 was 93.5% (29/31),with 21 cases reaching ACR20(67.7%),8 cases reaching ACR50(25.8%);the control group reaching ACR20 or ACR50 was 81.3%(25/32),with 24 cases reaching ACR20(75%),2 cases reaching ACR50(6.3%).There was significant difference between the two groups(P<0.05).3 Comparison of symptoms and signsIntra-group comparisons of both 2 groups showed that there was a significant difference(P<0.01)in the number of swollen and tender joints,morning stiffness time,TCM symptom score and VAS pain score.Comparison between groups indicated that the difference in the number of swollen and tender joints,TCM symptom score,VAS pain score were statistically significant(P<0.05),while the difference in morning stiffness time between the 2 groups was not obvious(P>0.05).4 Comparison of PGA,EGA and DAS28 scoreIntra-group comparisons of both 2 groups showed that there was a significant difference(P<0.01)in PGA,EGA and DAS28 score before and after treatment.Comparison between groups indicated that the difference in PGA,EGA and DAS28 score were significant(P<0.05),So the test group is superior to control group.5 Comparison of laboratory indexIntra-group comparisons of both 2 groups showed that there was a significant difference in ESR,CRP and RF after 8 weeks of treatment in contrast to pretreatment.Comparison between groups indicated that the difference ESR,CRP and RF between the 2 groups was not statistically significant(P>0.05),,So the test group is not superior to control group.6 Comparison of the quality of life scoreIntra-group comparisons of both 2 groups showed that there was a significant difference(P<0.01)in HAQ score and PRO score after treatment in contrast to pretreatment.Comparison between groups indicated that the difference in in HAQ score and PRO score were statistically significant(P<0.05),So the test group is superior to control group.7 Comparison of safetyIn test groups,there are 1 patient with gmild diarrhea,and in the control group,there are 1 patient with abnormal liver-function.By symptomatic treatment,all symptoms are improved.The urinary,stool and blood routine test,liver functions,liver-function,electrocardiogram of both groups were within the normal range befor and after treatment.ConclusionsTreating damp heat stasis syndrome of active rheumatoid arthritis by Ertu removing dampness and dredging arthralgia prescription combined with Leflunomide Tablets or Shirebi granule combined with Leflunomide Tablets can both alleviate the clinical symptoms,reduce the index,improve patient’s quality of life.What is more,the combination of tradition Chinese medicine and Western medicine had low side effects.There wsa a significant difference in the reduction of the tender joint and swollen joint number,TCM symptom score,VAS pain score,disease activity and improve patient’s quality of life beteewn the two groups(p>0.05),which reveals the treatment with Ertu removing dampness and dredging arthralgia prescription is superior to Shirebi granule.Obviously,it can be seen that the prescription combined with Leflunomide Tablets has good clinical efficacy and safety in the treatment of damp heat stasis syndrome of active rheumatoid arthritis.In addition,this prescription has integrated the theory of TCM with modern pharmacology,showing the advantages of combining disease differentiation with syndrome differentiation in TCM.In general,this prescription is worthy of further research and application in clinic.