Effect Of Prolonged Total Course Of Treatment On Prognosis Of Patients With ?a (N2) Stage Non-small Cell Lung Cancer

Background:The prognosis of patients with stage ?a non-small cell lung cancer?NSCLC?is poor,and recurrence and distant metastasis are prone to occur.There are a large number of retrospective studies pointing out that N2 patients with postoperative pathology are assisted.Radiotherapy is of great significance,improving overall survival and reducing the chance of relapse.In clinical work,due to radiotherapy machine malfunctions,holidays,patient compliance,and other factors,resulting in prolonged RTT.The current prolongation of the total duration of radiotherapy indicates poor survival rates in some malignancies^[1]such as?head and neck cancer,cervical cancer?have been reported,there are also some studies suggesting that the prolongation of RTT in NSCLC can affect the prognosis of patients.Therefore,understanding the impact of RTT on the prognosis and guiding our interventions in time is of great significance.Objective:To investigate the effect of prolonged radiation treatment time?RTT?upon the survival of patients with stage ?a?N2?NSCLC who received definitive Postoperative adjuvant radiotherapy;Methods:From May 2009 to December 2012,100 patients with stage ?a?N2?NSCLC who received definitive Postoperative adjuvant radiotherapy were retrospectively analyzed;with a median of 39d,All patients were divided into RTT>39 days group and RTT?39 days group,The treatment outcomes between the two groups were analyzed.The influence of prolonged RTT upon the survival of patients was assessed by Kaplan-Meier survival analysis.Clinical prognosis was evaluated by Cox regression analysis.Results:The 1-,3-,and 5-year actuarial survival rates were 61%,36%,and 23%respectively.Compared with patients treated with R TT>39 d,the overall survival?HR=1.694,95%CI 1.013².832,P=0.045?and progression free survival?HR=1.712,95%CI 1.036².829,P=0.036?of patients who treated with RTT?39 d was significantly higher.The results of multiple factors COX regression showed that the independent risk factors included T grades,N2 metastasis groups,and prolonged RTT.Conclusion:Prolonged RTT?>39 d?can decrease the survival of patients with stage ?a?N2?NSCLC who had received definitive Postoperative adjuvant radiotherapy.