Therapeutic Effect Of ¹²⁵I Radioactive Particle Implantation On Hepatic Malignant Tumor

Objective:To observe the short-term therapeutic effect of ¹²⁵I radioactive seeds implanted in the treatment of hepatic malignancies and explore the clinical significance of radioactive particle implantation.Methods:A retrospective analysis was performed on the clinical data of patients undergoing ¹²⁵I radioactive particle implantation in our hospital from 2015-5to 2017-7.Collected the clinical data of patients who were screened according to the case selection criteria.Clinical datas included basic information:age,gender,primary tumor site,liver metastasis or not,particle implantation surgery information:date of surgery,number of particles used,adverse reactions and complications that happened after surgery,laboratory examinations:the variety of liver function before surgery,one month after surgery and three months after surgery,image data:an abdominal enhanced CT before surgery,another in one month after surgery,and the third in three months after operation,follow-up information:follow-up of abdominal enhanced CT,survival status,or causes of death for every three months.According to those abdominal CTs and the solid tumor evaluation criteria RECIST version 1.1 to evaluate short-term efficacy.Using repeated measurement data analysis of variance to observe the trend of liver function.Cox regression analysis factors affecting postoperative life time.Results:1.Short-term efficacy:The effective rates at 1 and 3 months after surgery were 41.7%?20/48?and 77.1%?37/48?,respectively.The effective rate of postoperative three months in patients with?3 metastases and diameters>3 cm was 77.8%?14/18?and 71.9%?23/32?,respectively.In addition,all treatment lesions were reduced to varying degrees and no local recurrence?intralesion or recurrence of lesion edges?occurred during follow-up visit.The local control rate was 100%.However,8 patients in the follow-up visit had new intrahepatic metastases.2.The incidence of postoperative adverse reactions was 20.8%,which was characterized by pain in the operation area?5 cases?,nausea?4 cases?,and fever?1 case?.The above symptoms all disappeared within 48 hours and did not reappear during follow-up.No serious surgical-related adverse events and complications were observed in this study.3.There was no significant difference in changes of liver function index before and after surgery?P>0.05?.4.Cox regression analysis showed that the patient's age,gender,type of primary tumor,liver metastases or not,history of hepatic tumor treatment,diameter of lesions,and number of lesions were not correlated with survival time?P>0.05?.Conclusion:1.The implantation of radioactive particles can effectively treat local lesions.It has the advantages of less adverse reactions and less damage to liver function.It is a safe and effective treatment.2.Radioactive particle implantation provides new treatment opportunities for patients with large lesions,multiple lesions,and poor liver function.3.The clinical significance of radioactive particle implantation is a local treatment.This method can effectively control the progress of local lesions and help improve the quality of patients'Iife.Its clinical application deserves further study.