Bone Turnover Markers Research In Young Men With Different Obesity Phenotype

In recent years,obesity has been found to be distinguished between different forms.In the new century Metabolically Healthy but Obese?MHO?is going into the field of vision.The obesity phenotypes,unlike traditional obesity,in there are obesity but no metabolic risk factors.Bone metabolism disorders have become more common in our society where aging is gradually increasing.Recent studies show that obesity is associated with bone metabolism.This research,by looking at young male obese different phenotypic relationship with the concentration of serum bone metabolic markers,study different effect on bone metabolism of different obesity condition.This study for guiding obese bone metabolic diseases prevention and control is of great importance.Objective:Observed young-aged men different obesity phenotype crowd bone metabolic markers level,analysis the influence and correlation of different metabolic obesity phenotypes and bone metabolism.Methods:Selecting 173 young-aged men,divided into metabolism healthy normal weight group of 32 cases,metabolism healthy overweight of 37 cases,metabolic healthy obese group of 30 cases,metabolism unhealthy obesity of 74 cases,compared four groups of general data and bone metabolic markers?P1NP,CTX,OC?and analyze the relevance.Results:1 The femoral neck bone density in the MUO group was significantly higher than that in the MHNW?P=0.044?and MHOW?P=0.045?groups.There was no significant difference in the other two groups of bone density?femoral neck?contrasts?P>0.05?.There was no significant difference in bone mineral density?L₁^L₄?and bone density?total?between the four groups?P>0.05?.There was no significant difference in age between the four groups?P>0.05?.The BMI of the MHOW group?P=0.018?,the MHO group?P<0.001?,and the MUO group?P<0.001?was significantly higher than that of the MHNW group.The BMI in MHO group?P<0.001?and MUO group?P<0.001?was higher than that in MHOW group.There was no significant difference in BMI between MHO group and MUO group?P>0.05?.The FBG,2hPG,and HOMA-IR in MHOW group,MHO group,and MUO group were significantly higher than those in MHNW group?P<0.05?.The FPG in MUO group was significantly higher than that in MHO group?P<0.05?.FBG,2hPG,and HOMA-IR difference between other two groups was not statistically significant?P>0.05?.The systolic and diastolic pressures in the MUO group were significantly higher than those in the MHNW group,the MHOW group,and the MHO group?P<0.001?.The systolic blood pressure in the MHOW group and the MHO group was significantly higher than that in the MHNW group?P<0.05?.There was no significant difference in diastolic blood pressure between the two groups?P>0.05?.The TG of MUO group was significantly higher than that of MHNW group,MHOW group and MHO group?P<0.001?,and there was no significant difference in the other two groups of TG?P>0.05?.The HDL-c in MHNW group was significantly higher than that in MHOW group,MHO group and MUO group?P<0.001?,MUO group was lower than MHOW group and MHO group?P<0.05?,and the difference in HDL-c between the other two groups was not statistically significant?P>0.05?.2 P1NP levels were significantly lower in the MUO group than in the MHNW group?P<0.001?,and there was no significant difference in P1NP between the other two groups?P>0.05?.CTX levels in MUO group were significantly higher than those in MHNW group and MHOW group?P<0.001?.CTX levels in MHO group were higher than those in MHNW group?P<0.001?.There was no significant difference in CTX levels between the other two groups?P>0.05?.OC levels were significantly lower in the MHOW and MUO groups than in the MHNW group?P<0.001?.There was no significant difference in the OC level between the other two groups?P>0.05?.3 After correlation analysis of the three groups with normal metabolism?OW group,NW group,and MHO group?,BMI was positively correlated with BMD?totalbody??r=0.275,P=0.002?,age?r=0.237,P=0.018?,FBG?r=0.556,P<0.001?,and 2hPG?r=0.341,P=0.001?and negatively correlated with HDL-c?r=-0.432,P<0.001?and OC?r=-0.250,P=0.013?.P1NP was negatively correlated with FBG?r=-0.327,P<0.001?.CTX was positively correlated with BMI?r=0.451,P<0.001?and FBG?r=0.296,P=0.003?.OC was positively correlated with HDL-c?r=0.235,P=0.019?and with BMI?r=-0.250,P=0.013?,FBG?r=-0.533,P<0.001?,2hPG?r=-0.278,P=0.005?was negatively correlated.HOMA-IR was positively correlated with FBG?r=0.300,P=0.001?,CTX?r=0.230,P=0.022?and negatively correlated with OC?r=-0.278,P=0.005?.4 After correlation analysis of each index in group MUO,it was found that P1NP was positively correlated with OC?r=0.242,P=0.038?,and negatively correlated with HOMA-IR?r=-0.337,P=0.003?and FBG?r=-0.390,P=0.001?.OC is positively related to P1NP?r=0.242,P=0.038?,negatively related to CTX?r=-0.280,P=0.016?,BMI?r=-0.286,P=0.013?and FBG?r=-0.286,P=0.013?.CTX is positively related to BMI?r=0.255,P=0.028?and negatively related to OC?r=-0.280,P=0.016?.5 P1NP,CTX,and OC were divided into lower and higher groups with P50?median?.After assignment?when analyzing OC:lower group=1,higher group=0,using MHNW group as a control;analysis of P1NP:lower group=1,higher group=0,using MHNW group as a control;when analyzing CTX,lower group=0,higher group=1,using MHNW group as a control?After logistic regression analysis,it was found that the opportunity reduced in serum OC level of MUO group was 6.593 times that of MHNW group?OR=6.593,P<0.001,95%CI:2.513-17.297?.The opportunity reduced inMHOWgroupwas6.593timesthatofMHNW group?OR=6.593,P=0.001,95%CI:2.248-19.340?.Theopportunityof decrease in serum P1NP levels of the MUO group was 4.198 times higher than that of the MHNW group?OR=4.198,P=0.002,95%CI:1.703-10.353?;the opportunity of increase in serum CTX level in the MUO group was11.250timeshigherthanthatoftheMHNW group?OR=11.250,P<0.001,95%CI:3.854-32.837?.The opportunity of increase in MHO group was 7.062 times that of the MHNW group?OR=2.134,P=0.001,95%CI:2.134-23.367?.Conclusion:1 Different obesity phenotypes in young men have different levels of serum bone metabolic markers.Compared with MHNW young men,MUO and MHO young men are more likely to have higher serum CTX levels,with MUO being more likely than MHO;MUO young men are more likely to have lower serum P1NP levels.2 In the metabolism of healthy young men with the increase of BMI,bone mass may be increased,that beneficial for bone health,but at the same time CTX as well as the break the bone markers increases with the rise,so the obese people even without metabolic abnormalities,can still exists the risk of loss of bone mass.3 Obese young males with metabolic abnormalities had a higher bone density than those with normal weight,but the decrease opportunity in serum P1NP was 4.198 times higher than normal healthy weight,and as their BMI increased,CTX serum levels increased,and serum levels of OC decreased,suggesting that with the increase of body weight and the presence of abnormal metabolic parameters,the crowd's bone metabolic activity increases osteoclastic activity and bone synthesis decreases,and there is also a risk of bone mass reduction.In particular,attention should be paid to the prevention of metabolic diseases and bone diseases in such populations..