Pulmonary Function In Patients With Asthma-COPD Overlap

Objective: To investigate the features of lung function in patients with asthma-COPD overlap,and to increase awareness of patients with asthma-COPD overlap.Method: This article included 172 subjects who visited the General Hospital of Tianjin Medical University from April 2016 to October 2017.All subjects were recorded for gender,age,height,weight,body mass index,smoking history,and past medical history.All subjects underwent pulmonary function and impulse oscillation system.they were then divided into ACO group(n=40),COPD group(n=50),asthma group(n=42),Control group(n=40).Pulmonary ventilation function parameters were compared among groups of subjects: FEV1?FVC?FEV1/FVC?PEF?MMEF?MEF75?MEF50?MEF25?RV?TLC?RV/TLC;Pulmonary diffusion function index: Diffusion of carbon monoxide(DLco);IOS indicators: Fres?Zrs?X5?R5?R10?R15?R20?R5-R20.To investigate the features of lung function in patients with asthma-COPD overlap.Result: 1.The data of the each group the average age of Control group(57.95±8.68)years old,the average age of asthma group(55.52±12.22)years old,the average age of COPD group(69.98±8.36)years old,the average age of ACO group(62.73±9.27)years old.there had difference in ACO and COPD group in gender.There had no significant difference in height,weight and body mass index between the four groups.there had difference in ACO and COPD groups in gender.2.Comparison of lung function indexes ACO group FEVI(47.59±15.14)%,FVC(70.83±15.74)%,FEV1/FVC(53.56±9.44)%,PEF(48.07±17.42)%,MEMF(17.20±7.44)%,MEF75(25.62±13.47)%,MEF50(17.04±7.44)%,MEF25(18.31 ±9.22)% were lower Compared with control group and asthma group(P< 0.05)and There was no significant difference between ACO group with COPD group(P>0.05).There was no significant difference in the RV index between the four groups.ACO group TLC(72.41±13.51)% was significantly lower than the control group and the asthma group(P<0.05),but there was no significant difference with COPD group.The RV/TLC(44.19±10.63)% in the ACO group was significantly different from that in the control group,the asthma group,and the COPD group(P<0.05).there had difference in DLco(69.01±14.46)% between the ACO group and the control group,the asthma group,and the COPD group(P<0.05).3.Comparison of IOS indicators the ACO group compared with the control group Zrs(177.73±36.22)%,Fres(21.60±5.34)[1/s],R5(152.24±26.54)%,R10(116.99±25.52)%,R15(106.20±24.41)%,R20(101.30±23.11)%,R5-R20(394.93±36.27)%,X5(308.97±26.90)% increased significantly(P<0.05);ACO Compared with asthma group,R5-R20 significantly increased,R20 significantly decreased(P<0.05);compared with COPD group,there was no significant difference(P>0.05).Conclusion: 1.In terms of lung function: ACO patients have worse lung function than asthma patients.Patients with ACO and COPD have similar pulmonary ventilation function,but less diffuse function and less emphysema.2.In terms of airway resistance: Airway resistance increased in patients with asthma,COPD,and ACO.Central airway resistance in patients with ACO and COPD was lower than that in asthmatic patients.Peripheral airway resistance was higher than in asthmatic patients.