Prevalence And Associated Factors Of Cancer-Related Fatigue Among Lung Cancer Patients

Objective: The goal of this study was to determine the prevalence of and factors associated with Cancer-related fatigue(CRF)among lung cancer patients in Tongji Hospital of Huazhong University of Science and Technology.Methods: The BFI(Simple Fatigue Inventory)questionnaire was used to investigate the fatigue of lung cancer patients in Tongji Hospital of Huazhong University of Science and Technology.Through the electronic medical records system,to collect the patient's demographic characteristics and diagnosis and treatment information.Statistical analysis was performed using SPSS 23.O.Result:1.In this study,a total of 85 patients diagnosed with lung cancer completed BFI questionnaire,including 58 males and 27 females,the median age of 54 years,age distribution to meet the normal distribution.ECOG score of 1 for the 66 patients,scored 2 for the 14 patients,the score of 3 patients for 5 people.Lung adenocarcinoma patients were 47 people,lung squamous cell carcinoma patients for 22 people,lung small cell carcinoma patients for 14 people,pulmonary lymphoma epithelioid carcinoid and pulmonary mucoepithelial carcinoid each have 1 person.According the TNM,patients were divided into I,II,III,IV,patients were 10,8,13,54 people.The patients who completed the investigation were classified according to the treatment stage: 8 patients who had been diagnosed as lung cancer but had no previous anti-tumor therapy;23 patients who are going to adjuvant chemotherapy or undergoing adjuvant chemotherapy;35 patients who are undergoing palliative chemotherapy;17 people who are receiving molecular targeted drug therapy;2 people who are survivors.No patients with lung cancer who are chest radiotherapy are involved in the investigation.In this study more patients in the palliative chemotherapy,followed by adjuvant chemotherapy stage after surgery.2.This study showed that the prevalence of CRF in lung cancer patients was 50.6%,the prevalence of moderate to severe fatigue was 27.1%.3.Different ECOG scores of patients,the prevalence of fatigue and light,moderate,severe fatigue are different,the worse the general condition of patients,the higher ECOG score of patients,the prevalence of fatigue is higher,the prevalence of moderate to severe fatigue is higher.Different HB cases of patients,the prevalence of fatigue and light,moderate,severe fatigue are different,anemia patients with a higher prevalence of fatigue and a higher prevalence of moderate to severe fatigue.There was no significant difference in the distribution of the prevalence of fatigue between different sexes,age,tumor type,tumor stage and tumor treatment stage.With or without bone metastases,with or without lung surgery,with or without chest radiotherapy,with or without leukopenia,between the groups the prevalence of fatigue distribution was no significant difference.4.Fatigue has interfered daily life of lung cancer patients.The greatest impact is on the enjoyment of life,followed by a greater impact on the normal work,the least impact is on the relationship with others.In addition,the correlation analysis shows that the degree of normal work is most correlated with the degree of fatigue.5.Logistic regression analysis showed that only the ECOG score,that is,the physical condition of lung cancer patients is the only statistically significant influencing factor with CRF in lung cancer patients(P <0.05).Other factors,such as Patient demographic characteristics(gender,age,tumor staging)? previous treatment(surgery,radiotherapy,chemotherapy,targeted therapy)? serological tests(leukocytes,hemoglobin),are not significant influencing factors(P>0.05).Conclusion: 1/2 of lung cancer patients will suffer from fatigue,1/4 of lung cancer patients will feel moderate to severe fatigue.Patients with poor physical condition or low hemoglobin are correlated with a higher prevalence of fatigue,and a higher prevalence of moderate to severe fatigue.Unfortunately,the physical condition of the lung cancer patient(the ECOG score)was the only factor affecting the prevalence of fatigue,and the patient with poor physical condition was more likely to develop fatigue.Fatigue affects the daily life of the patient,especially the enjoyment of life and normal work.We need to pay more attention to the management of fatigue among lung cancer patients,such as pain,nausea and vomiting be attended.We should assess,evaluate,manage,and then again assess the fatigue of lung cancer patients.