| Objective:1.Comparison of short-term and long-term effects of different combination therapy regimens in the treatment of advanced gastric cancer.2.Different treatment of patients with advanced gastric cancer in patients with adverse reactions.Methods:A total of 227 patients with advanced gastric cancer were enrolled in this study from April2012 to October 2016.Among them,the observation group was treated with docetaxel,oxaliplatin and tiggio in combination with chemotherapy;The control group using oxaliplatin,tiggio two drugs combined with chemotherapy,a total of 100 cases,and comparative analysis of the two groups of patients with clinical efficacy,immune function and adverse reactions.SPSS17.0 software package for statistical analysis.The quantitative data in the data are expressed by the mean ± standard deviation(x ± s).When comparing the differences between the quantitative indexes,the Kolmogorov-Smimov method is used to check the regularity of the quantitative data.If the normal distribution is normal(ANOVA)and post-hoc post hoc test were used to analyze the LSD or Tambane’s T2 test.Pearson or Spearman correlation analysis was used to analyze the correlation between variables.Survival analysis using kaplan-meier experience.Results:1.The total effective rate was 53.5% in the observation group,which was 40.0% higher than that in the control group(P<0.05).The control rate of the observation group was87.4%,which was higher than that of the control group(78.0%),but the difference was not statistically significant(P> 0.05).2.There was no significant difference between the two groups before treatment(P>0.05).There was no significant change in CD3 + before and after treatment(P> 0.05).CD4+ / CD8 + were significantly lower in the two groups than those before treatment(P<0.05).There was no significant difference between the two groups(P> 0.05).CD3 +,CD4 +,CD8+ and CD4 + / CD8 + were not statistically significant in the observation group compared with the control group(P> 0.05).3.PFS was 2.4 months-7.9 months and the median PFS was 4.9 months.The median PFS was 5.0 months in the observation group and 4.9 months in the control group,the difference was not statistically significant(P> 0.05)The The OS was 6.6 months-16.8months and the median OS was 10.8 months.The median OS was 11 months(2 patients lost)and 10.7 months in the control group(1 patient lost),The difference was not statistically significant(P> 0.05).4.The observation group of patients with adverse reactions are Ⅰ ~ Ⅲ degrees,does not affect the treatment,the control group,3 patients with alopecia degree Ⅳ,after symptomatic treatment to ease,the rest are Ⅰ ~ Ⅲ degrees.The proportion of adverse reactions in the observation group was higher than that in the control group,but the difference was not statistically significant(P> 0.05).Conclusions:1.Oxaliplatin,tiggio combined with docetaxel chemotherapy in the treatment of advanced gastric cancer than oxaliplatin,tiggio two drugs combined with the total effective rate of chemotherapy,but the disease control rate is quite.2.Oxaliplatin,tiaglio combined with docetaxel chemotherapy with oxaliplatin,tirogo two drugs combined with chemotherapy Median progression-free survival time,median overall survival time is similar.3.Oxaliplatin,tiggio combined with docetaxel in the treatment of advanced gastric cancer did not increase the risk of adverse reactions and the risk of immune dysfunction. |
PDF Full Text Request