Research Progress On The Protective Effect Of Rho Kinase Inhibitor On Optic Nerve Injury

The optic nerve belongs to the conduction beam of the central nervous system.The optic nerve damage is essentially the degeneration and programmed apoptosis of the retinal ganglion cells(RGC)that constitute the optic nerve.The current pathogenesis is not yet completely clear.Over the years,studies have shown that glial cells,microglia,nitric oxide,mitochondria and calcium ions,myosin light chain(MLC)phosphorylation and dephosphorylation,nerve cell apoptosis and other factors All can inhibit the repair and regeneration of optic nerve axons and participate in optic nerve injury.The current way of repairing the optic nerve after injury remains controversial.With the development of science and technology such as stem cells and molecular biology,new therapeutic methods focus on preventing or delaying apoptosis of retinal ganglion cells and repairing damaged axons.Therefore,protection therapy after optic nerve damage has become the target of current research.Recent studies have shown that Rho-kinase-related inhibitors can antagonize Rho kinase(ROCK)signaling pathway,inhibit inflammatory factors,and improve the inflammatory microenvironment;strengthen the release of neurotrophic factors and support neuronal growth;and reduce vascular smooth muscle contractility,increase blood supply;reduce the activity of Cysteinyl aspartate specific proteinase-3(Caspase-3),inhibit apoptosis and so on.With the deepening of research,the protective effect of Rho-kinase inhibitor Fasudil after nerve injury has been confirmed,but the protective effect of optic nerve damage is rarely reported.Therefore,this article focuses on the restoration and protection of Rho-kinase inhibitor fasudil after optic nerve damage in order to guide clinical drug use and provide new ways for the study of new drugs.