Application Of Metronomic Chemotherapy In Metastatic Breast Cancer And Its Research Progress

In the world,malignant tumors are a serious threat to people's health.Breast cancer is the most important among women.The metastatic breast cancer(MBC)is the stage of advanced breast cancer,regardless of the treatment method,treatment effect and prognosis are different from early breast cancer.The treatment of metastatic breast cancer includes chemotherapy,endocrine therapy,targeted therapy,and radiotherapy.With the continuous deepening of the treatment of metastatic breast cancer,a variety of treatment options combined application has become a research hotspot.With the continuous advancement of diagnostic techniques and treatment methods,clinical trials have adopted chronic disease management models for advanced breast cancer patients to control the tumor as long as possible,prolong patient life and improve patient quality of life.Metronomic chemotherapy(Metronomic Chemotherapy MC)is a good choice for patients with metastatic breast cancer.The beat-chemotherapy model uses short-term,short-term doses that are economical,well-tolerated and have no cumulative toxicity.There is a certain degree of disease control,and the incidence of adverse events is low.Its mechanism of action includes anti-tumor angiogenesis,immune regulation,stem cell production,etc.The efficacy and tolerability are good in patients with metastatic breast cancer.This review focuses on the use of beat or rhythm chemotherapy in the treatment of metastatic breast cancer in combination with endocrine drugs,molecular targeted drugs,and immunotherapeutics.