Magnetic Resonance Spectrum Research On Bipolar Disorder Patient With Aggression

Objective: To investigate the prefrontal lobe function in patients with bipolar disorder with impulsive aggressive behavior using magnetic resonance spectroscopy(MRS),so as to explore the possible relationship between impulsive aggressive behavior and prefr ontal brain hippocampus function in patients with bipolar disorder from the perspectiv e of brain function.Methods: A total of 24 patients Starting not cure patients with bipolar disorder(10cases with impulsive aggressive behavior,and 14 with non-impulsive aggressive behavi or)were enrolled and studies by case-control study.The modified overt aggression beh avior scale(MOAS)and the Barratt Impulsiveness Scale 11(BIS-11)were used to ev aluate the included subjects.Magnetic resonance spectroscopy(MRI)scans were perfor med on the subjects using 3.0T magnetic resonance imaging equipment.NAA/Cr,Cho/Cr,and Glx/Cr ratios were analyzed quantitatively.Results: 1.There were no significant differences in impulsivity,aggression,sex,occup ation,education,and financial status and impulsive attack groups of the impulsive att ack group(P>0.05).2.In the impulsive attack group and the non-impulse challenge group,the left prefron tal cortex NAA/Cr value was significantly lower than the impulsive challenge group,a nd the difference was statistically significant(P<0.05).3.Comparing the caudal prefrontal Cho/Cr value,GlX/Cr value,the right prefrontal cortex and bilateral hippocampal NAA/Cr value,Cho/Cr value,GlX/Cr value There was no significant difference between Cr value and non-impulse group(P>0.05).Conclusion:1.In patients with bipolar disorder with impulsive aggressive behavior,there may be a decrease in the density of the left prefrontal neuron or neuronal dysfunction compar ed with the impulsive challenge group.2.Compared with the non-impulse challenge group,patients with bipolar disorder with impulsive aggressive behavior had no abnormal cell membrane function and abnormal concentrations of glutamate and γ-aminobutyric acid neurotransmitters in the left prefr ontal cortex.3.Compared with the non-impulse attack group,patients with bipolar disorder with impulsive aggressive behavior showed no decrease in neuronal density or neuronal dysfunction in the right prefrontal and bilateral hippocampus,and no abnormal cell membrane and glutamine were found.Acid,γ-aminobutyric acid neurotransmitter concentrations are abnormal.