Retrospective Analysis Of 634 Cases Of Neonatal Jaundice In A Hospital Of Qiqihar City

Objective:We collected the general situation,mother condition,etiology of jaundice,high risk factors,clinical manifestations and examination results of children during hospitalization by consulting the case data of newborns with jaundice in a hospital in Qiqihar City.We described the information of treatment,complications,prognosis and hospitalization expenses.Then the factors affecting the severity of neonatal jaundice,the factors affecting the therapeutic effect and the factors related to the cost of hospitalization were analyzed.This research provided a scientific reference for the diagnosis,treatment and prevention of neonatal jaundice in this area.Methods:The cases of neonatal jaundice hospitalized in a hospital in Qiqihar city were collected and analyzed retrospectively from July 1,2016 to December 31,2017.Excel2007 was used to input data,and SPSS 22.0 software was used to sort and analyze the data.Frequency and frequency were used to describe counting data.Means,standard deviations and quartile were used to describe measurement data.Chi-square test and the Fisher exact probability test were used to compare the severity of jaundice and therapeutic effect among different groups.The rank sum test was used to compare the relationship between different factors and the cost of treatment.Two-classification logistic regression analysis was used to analyze the factors that might influence the severity and therapeutic effect of neonatal jaundice.All statistical analysis results were P<0.05 as a statistically significant test level.Results:1.The basic information of newborn jaundice childrenA total of 634 cases of neonatal jaundice were collected in the retrospectiveanalysis,with a male to female ratio of 1.11:1.Early neonates and non-premature infants were the main ones.The average birth weight of the children was 3056.49 g.Breast feeding accounted for 40.22% and cesarean section with 71.92%.Jaundice occurred within 5 days before birth.2.Maternal status of newborns with jaundiceAmong the ABO blood groups,the mothers with AB type blood were the least.There were 499 cases of first delivery by mothers,and 14.35 cases were old women.Premature rupture of membranes,intrauterine distress,amniotic fluid,umbilical cord history of abnormal pregnancy were the main conditions during pregnancy.3.Treatment of neonatal jaundiceThere were 51 children with severe jaundice before treatment.All cases were treated with phototherapy,and some cases were treated with other adjuvant therapy.Adverse reactions occurred during treatment with fever,diarrhea,and rash.The effective rate of treatment was 94.95%.4.Analysis of severity of neonatal jaundiceIn the univariate analysis,chi square test and Fisher exact probability method were used,birth weight,gestational age,delivery mode,premature rupture of membranes,feeding,internal bleeding,infection,increased intestinal and hepatic circulation,hypoxia,sepsis,hyperthermia,hypoglycemia were associated with the severity of neonatal jaundice.There were significant differences in the incidence of severe jaundice among different groups(P<0.05).Logistic regression analysis showed that feeding,hemorrhage,hypoxia and hypoglycemia were related to the severity of neonatal jaundice.5.Analysis of therapeutic effect of neonatal jaundiceIn univariate analysis,chi-square test showed that the time of jaundice,maternal blood group,hemolysis,probiotics,intravenous albumin and exchange of blood were significantly different in the treatment of neonatal jaundice(P<0.05).Logistic regression analysis showed that oral probiotics could effectively improve the therapeutic effect of neonatal jaundice.6.Cost of treatment for neonatal jaundiceThe average hospitalization cost of neonatal jaundice was 6647.48 yuan,the median was 5574.62 yuan,the minimum was 2631.03 yuan,and the maximum was44332.03 yuan.By rank sum test,sex,birth weight,gestational age,delivery mode,feeding method,time of occurrence of jaundice,age of mother,number of births,premature rupture of membranes,abnormal diseases of pregnancy and amniotic fluid were all related to the cost of hospitalization.The difference was statistically significant(P<0.05).Conclusion:1.Feeding pattern,hemorrhage,hypoxia and hypoglycemia were related to the severity of neonatal jaundice.2.Adequate breastfeeding can effectively reduce bilirubin levels and promote and encourage breastfeeding.3.To avoid bleeding in the body,preventing participants from chronic hypoxia,and actively preventing and correcting hypoglycemia was useful to control and reduce the occurrence of severe jaundice in newborns.4.Oral probiotics was related to the therapeutic effect of children.Oral probiotics can effectively improve the therapeutic effect of neonatal jaundice.