Characterization Of Ocular Biometrics And Aqueous Humor Dynamics In Preclinical Stage Of Acute Angle-closure Glaucoma

Objective: The ocular biometrics and aqueous humor dynamics(AHD)parameters of healthy volunteers and patients with acute angle-closure glaucoma(AACG)at preclinical stage were detected and analyzed.Methods: Elderly healthy volunteers(Control group,C)and preclinical stage of AACG patients(Experimental group,E)completed the study.Parameters investigated were axial length(AXL),anterior chamber depth(ACD),anterior chamber volume(ACV),central cornea thickness(CCT),intraocular pressure(IOP),aqueous flow(Fa),outflow facility(C),episcleral venous pressure(EVP),and uveoscleral outflow(Fu).Comparisons and correlations were made between and within groups.Results: In healthy volunteers,ocular biometric parameters,IOP,and EVP correlated very well between the two eyes of each individual,but Fa,C,and Fu were not significantly correlated.Biometric parameters of the AACG at preclinical phase group significantly(p<0.001)differed from those of the healthy controls: AXL(23.31 ± 1.03 mm [E] vs 22.39 ± 1.04 mm [C];mean ± SD),ACD(2.44 ± 0.33 mm [E] vs 1.86 ± 0.25 mm [C]),ACV(136.0 ± 36.1 ?L [E] vs 81.4 ± 21.8 ?L [C]),CCT(526.9 ± 37.0 ?m [E] vs 556.1 ± 28.4 ?m [C]).There was no significant change in IOP,Fa,C,EVP,or Fu between Control and Experimental group.Furthermore,IOP showed no significant correlations with AXL,ACD,ACV,CCT in both groups.Conclusions: The AACG at preclinical phase eyes had a shorter AXL,a shallower ACD,and a smaller ACV,but a thicker CCT.Despite these morphological changes,the AACG at preclinical phase eyes did not have any significant changes in IOP,and AHD parameters.This is consistent with the findings that IOP did not show significant correlations with biometrics.