| Objective: By studying the Traditional Chinese Medicine physique types and CISS etiology of patients with acute cerebral infarction,combined with ApoE genotypes,this thesis aims to explore the distribution of pathological physique types and susceptibility genotypes,and tries to provide individualized treatment for patients of pathogenesis in acute cerebral infarction and to reduce the incidents and risk of stroke by preventive measures,ultimately to achieve the goal of preventing the diseases before their occurrence and avoiding their complications after occurrence.Methods: For this study clinical data of 153 cases of patients with acute cerebral infarction have been collected(including general information,related medical history,common risk factors,imaging and laboratory biochemical tests,etc.)the classification of the TCM physique types,ApoE genotypes,and CISS etiological types have been conducted and the data have been analyzed using SPSS Ver.20.0.Results:(1)The distribution of risk factors in 153 patients with acute cerebral infarction is alcohol(68cases,44.4%),smoking(65cases,42.5%),diabetes mellitus(58cases,37.9%),hyperlipidemia(45cases,29.4%),hypertension(42cases,27.5%),coronary heart disease(41cases,26.8%),family history(33cases,21.6%).(2)The main physique types of 153 patients are: mild physique type(42cases,27.5%),phlegm-dampness physique type(21 cases,13.7%)and Yang deficiency physique type(19 cases,12.4%).(3)The distribution of ApoE alleles in patients with acute cerebral infarction is: ApoE3(117cases,76.4%),ApoE2(25cases,16.4%)and ApoE4(11cases,7.2%).(4)The distribution of CISS etiology is: atherosclerosis(79cases,51.6%),percutaneous arterial disease(51cases,33.3%),atherosclerosis and percutaneous artery disease(10 cases,6.5%),cardioembolic stroke(6cases,3.9%),uncertain etiology(5cases,3.3%)and other causes(2cases,1.3%).(5)The distribution of lesions in 42 watershed infarction patients is: subcutaneous type(21cases,50%),cortex type(18cases,42.9%)and other type(3cases,7.1%).(6)The difference in the distribution of CISS etiology between patients of different physique types is statistically significant.The difference in the distribution of physique types,ApoE genotypes,and CISS etiology is not statistically significant.(7)The difference in the distribution of CISS etiology between the first onset and recurrent patients is statistically significant,while the difference in the distribution of physique types and ApoE genotypes is not statistically significant.(8)The difference in the distribution of physique types of young,middle-aged and elderly patients,in the distribution of CISS etiology is statistically significant.Conclusion:(1)The common risk factors of acute cerebral infarction are alcohol consumption,smoking history,diabetes,hyperlipidemia,hypertension,coronary heart disease and family history.(2)Mild physique type,phlegm-dampness physique type,Yang deficiency physique type are the main threatening physique types of acute cerebral infarction.(3)The most common ApoE genotype in patients with acute cerebral infarction is type ApoE3,with the predominant type being ε3/ε3.(4)Atherosclerosis,perforating artery disease are the main types in CISS etiology patients.(5)Subcortical type is the dominant type in watershed infarction patients,followed by cortical type and other type.(6)Atherosclerosis is the main type in mild physique type patients,while the type of CISS etiology is mainly other types(including cardioembolic stroke,other causes,etiological factors,mixed type).(7)Atherosclerosis and perinatal artery disease are the main types in first onset and recurrent patients,young,middle-aged and elderly patients with CISS etiology type.(8)The pathological physique types of young and middle-aged patients with cerebral infarction mainly include Qi stagnation,phlegm-dampness and damp-heat types.The pathological physique types of elderly patients with cerebralinfarction are Yang deficiency,Qi deficiency and phlegm-dampness types. |
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