Observation Of Rs-fMRI In Tinnitus Patients With Affective Disorder

Objective:The differences of restoring-state functional magnetic resonance imaging(rs-fMRI)between tinnitus combined with affective disorder and non-tinder were observed.To analyze the correlation between the different degrees of tinnitus and the changes of brain function.Methods:A retrospective analysis was performed on 19 patients with idiopathic tinnitus complicated with affective disorder admitted to the department of otolaryngology,XX hospital affiliated XX university from September 2013 to December 2018,and 15 healthy volunteers without tinnitus served as the control group.Tinnitus with affective disorder group and normal control group were treated with tinnitus handicap inventory(THI)and rs-fMRI.According to THI,tinnitus patients were divided into mild tinnitus group and severe tinnitus group.Using dpabi software to calculate the local consistent(regional homogeneity,ReHo),low frequency amplitude(amplitude of low-frequencyfluctuation,ALFF)and the low frequency fluctuation fraction amplitude(fractional amplitude of low frequencyfluctuation,fALFF).Double-sample t test and AlphaSim correction were performed for tinnitus group and control group、 mild tinnitus group and control group、severe tinnitus group and control group,respectively,to compare the brain image differences of patients with tinnitus combined with different degrees of emotional disorder.Result:(一)tinnitus group and control group:1.ALFF value: the brain regions of the tinnitus group with stronger ALFF value than the control group were left middle temporal gyrus and right rectus gyrus.The difference between the two groups was significant and statistically significant(P <0.05).The ALFF values of the tinnitus group were lower than those of the control group: right parahippocampal gyrus,left subparietal lobule,right precuneus.The difference between the two groups was significant and statistically significant(P <0.05)2.fALFF values: the fALFF values of the tinnitus group were stronger than those of the control group,including the left occipital medial gyrus and right precuneus.The difference between the two groups was significant and statistically significant(P <0.05)3.ReHo values:no significant differences(二)mild tinnitus group and control group:1.ALFF value:no significant differences2.fALFF value: the fALFF value of the mild tinnitus group was higher than that of the control group,which was left occipital medial gyrus.The difference between the two groups was significant and statistically significant(P < 0.05)3.ReHo values:no significant differences(三)severe tinnitus group and control group:1.ALFF value: the ALFF value of the severe tinnitus group was higher than that of the control group,and the brain areas were: left middle temporal gyrus,right superior frontal gyrus,left triangle inferior frontal gyrus,and left caudate nucleus.The difference between the groups was significant and statistically significant(P < 0.05)2.fALFF value:no significant differences3.ReHo values:no significant differences Conclusion:1.Different degrees of tinnitus are associated with different areas of abnormal brain function.The left middle occipital gyrus was significantly enhanced in the mild tinnitus group than that in the control group.In the severe tinnitus group,the left middletemporal gyrus,the right superior forehead gyrus,the triangular part of the left inferior forehead gyrus and the left caudate nucleus were significantly enhanced compared with the control group.2.Rs-fMRI may be an objective basis for grading the severity of tinnitus.