The Clinical Significance Of Fra-1 Gene Expression In Peripheral Blood Of Pediatric Children With Wilms' Tumor

Objective:To study the expression of the Fra-1 gene in the peripheral blood of children with Wilms' tumor and its clinical significance.Methods:Fifty children pathologically diagnosed with Wilms' tumor between December 2012 and January 2018 were enrolled as the case group,and 40 healthy children for physical examination were selected as the control group.Among the 45 children who were followed up,the children with continuous remission were included in the ideal efficacy group(n=33),and those with recurrence,metastasis,or death were included in the poor efficacy group(n=12).Peripheral blood were collected from all subjects.Quantitative real-time PCR was used to measure the mRNA expression of Fra-1.Results:The case group had significantly higher mRNA expression of Fra-1 in peripheral blood than the control group(P<0.05).In the case group,Fra-1 mRNA expression was significantly different between the individuals with and without distant metastasis and those with different TNM stages(P<0.05),but was not significantly different between the individuals with different sexes,ages,tumor diabetes,tumor locations,and alpha-fetoprotein levels(P>0.05).The expression of Fra-1 in the ideal efficacy group was lower than the poor efficacy group(P < 0.05).Conclusions:Fra-1 may be involved in the development of Wilms' tumor and play a certain role in its development,invasion and metastasis,but the specific mechanism remains to be further studied.