Relationship Between Macular GCIPL Thickness And Visual Acuity After Resolutian Of Diabetic Macular Edema

Objective:To assess the thickness of retinal fiber layer(RNFL),macular ganglion cell-inner plexus layer(GCIPL)and central macular thickness(CMT)in eyes with resolved diabetic macular edema(DME),using spectral-domain optical coherence tomography(HD-OCT),and its relationship with the visual function.Methods:This study retrospectively analyzed 30 cases of edema regression group(DME group)after treatment,and 30 cases of diabetic retinopathy without DME(no-dme group.).High-resolution coherent optical tomography(Cirrus-HD OCT)was used to measure the thickness of RNFL,GCIPL and CMT thickness in different regions,and analyzed the correlation between different thickness and visual acuity.Results:1.The average RNFL thickness of the DME group and the no-dme group was 102.33 9.32 m and 94.3 14.8 m,respectively.The comparison between the two groups was statistically significant(p=0.031),while the other quadrant comparisons were not statistically significant(p>0.05).2.There was no significant difference in CMT between the DME group and the non-dme group.The mean GCIPL thickness was 70.43 12.85 m,81.23 9.11 m(p=0.001),and the minimum value was 53.97 14.45,70.43 12.44(p<0.001).The GCIPL thickness of the DME group was thinner than that of the no-dme group in all the six determination areas,but there was no statistical significance p>0.05).3.In the DME group,19 eyes(63%)were treated with retinal laser photocoagulation(PRP group),and 11 eyes(37%)were not treated with retinal laser photocoagulation(no-prp group).There was no sisnificant difference in CMT thickness,average GCIPL thickness and minimum GCIPL thickness between the two groups(p>0.05).In the no-dme sroup,14 eyes(470%)were treated with retinal laser photocoagulation(PRP group),while 16 eyes(53%)were not treated with retinal laser photocoagulation(no-prp sroup).There was no significant difference in CMT thickness,GCIPL thickness mean and minimum values between the two groups(p>0.05).4.In the DME group,BCVA was significantly correlated with the average GCIPL thickness(r=-0.851,P<0.001)and the minimum GCIPL thickness(r=-0.669,P<0.001),while there was no correlation between BCVA and CMT(r=-0.237,P=0.208)and the RNFL average(r=0.050,P=0.791).The BCVA of the DME group was sisnificantly correlated with the average and minimum GCIP thickness,but not with the RNFL average and CMT.Conclusion:mGCIPL thickness decreased in the DME group compared with the no-DME group and was correlated with the visual acuity.These results suggested that inner retinal injury in patients with DME might lead to poor visual outcome after treatment.During the follow-up period after DME treatment,measurement of mGCIPL thickness using HD-OCT can be considered as one of the prognostic factors of visual acuity.