Epidemiological Investigation Of Occupational Stress And Hypertension And Interaction With Susceptibility Genes In Desert Oil Workers

Objective: Understand the occupational stress level and physical health of desert oil workers in Karamay City.According to the results of the cohort study,analyze the influencing factors of hypertension and the relationship with occupational stress.Using a case-control study,explore the effects of gene and gene,gene and occupational stress interaction on the prevalence of hypertension.Method: 1)A total of 3003 desert oil workers were selected from a group of 12 oilfield companies in Karamay City.The general situation questionnaire,occupational stress scale(OSI-R)and work ability index(WAI)were used to assess their physical health,occupational stress level and work ability;2)Based on the oil workers' queue established in 2013,1052 people from 3003 desert oil workers were selected to enter the cohort to explore the relationship between occupational stress and hypertension;3)PCR-RFLP was used to detect the polymorphisms of MTHFR and SELE genes in the hypertension group and the control group(155 people each),and to analyze the relationship between occupational stress,MTHFR,SELE gene polymorphisms and hypertension.Results: 1)Questionnaires were issued 3500 questionnaires,3003 questionnaire were recovered,and the recovery rate was 85.80%;2)Compared with the domestic norm,the desert oil worker's scores of the occupational role questionnaire and the personal stress questionnaire were higher,the scores of the personal resource questionnaire was lower;Males,drillers,college degree or above,and monthly income of ?3500 yuan have a higher level of occupational stress among workers;3)There was a statistical correlation between occupational stress and work ability.Work ability index(WAI)was negatively correlated with occupational role questionnaire(ORQ)and personal stress questionnaire(PSQ)scores,and positively correlated with personal resource questionnaire(PRQ)scores;4)There were differences in absenteeism rates between different gender,age,working type,educational level,and monthly income(P<0.05);5)Desert oil workers have the highest prevalence of musculoskeletal diseases(47.20%),and the lowest prevalence of blood diseases(4.76%).The prevalence of each disease increases with the increase of tension;6)The distribution of biochemical indicators such as total cholesterol and triglyceride among different occupational stress groups was statistically significant(P<0.05);7)A total of 1052 desert oil workers were followed up,the cohort retention rate was 70.13%,and the cumulative incidence of hypertension was 14.34%;8)Compared with the non-hypertensive group,the hypertension group had higher occupational stress level and lower resource response capacity;9)Males,age>40 years old,working year>15 years,shift,smoking and drinking have a high incidence of hypertension among workers;10)With the increase of occupational stress,the incidence of hypertension is increasing(P<0.05);11)Binary logistic regression model shows that age,shift,smoking,high occupational stress,role overload,role boundary,vocational strain will increase the risk of hypertension,social support and rational coping will reduce the risk of hypertension;12)SELE G98 T is related to hypertension,GT and TT genotypes are hypertensive susceptibility genotypes,MTHFR C677 T and A1298 C are related to hypertension,TT,AC and CC genotypes are hypertensive susceptibility genotypes.13)SHEsis software analysis showed that A-T of SELE and T-C of MTHFR are risk haplotypes for hypertension,A-G of SELE and C-A of MTHFR are protective haplotypes for hypertension.14)Using GMDR software analysis,C677 T,A1298C and occupational stress interaction model is the best.Regression analysis results showed that AA genotype at A561 C locus interacted with GT+TT genotype at G98 T locus,CT+TT at C677 T locus interacted with AC+CC at A1298 C locus,GT+TT genotype at G98 T locus interacted with AC+CC genotype at A1298 C locus were risk factor for hypertension,and AA genotype at A1298 C locus interacted with CT+TT genotype at C677 T locus was a protective factor for hypertension.After incorporating occupational stress factors,except for the A561 C locus,the interaction between other locus and occupational stress are risk factor for hypertension.Conclusions: 1)The occupational stress level of desert oil workers is higher than the national norm.Workers with male,drillers,junior college or above and monthly income of ?3500 yuan have higher occupational stress.There is a statistical correlation between occupational stress and work ability.The higher the occupational stress,the worse the work ability;2)The incidence of hypertension is positively correlated with occupational stress.Old age,shifts,smoking,high occupational stress,role overload,role boundary,vocational strain will increase the risk of hypertension,social support and rational coping will reduce the risk of hypertension;3)The SELE A561 C locus was not related to hypertension.GT,TT genotypes in G98 T and TT genotype in MTHFR C677 T,AC,CC genotypes in A1298 C are susceptibility genes for hypertension,gene-gene,gene-occupational stress interactions can affect the development of hypertension.