The Clinical Study Of Dicetabine Combined With Chemotherapy For Relapse And Refractory Acute Myeloid Leukemia

Objective:By comparing the efficacy of traditional chemotherapy combined with desitabine and traditional chemotherapy alone in the treatment of relapsed refractory acute myeloid leukemia,the differences in efficacy and the influencing factors were analyzed.Methods:Collect 62 cases of recurrence of refractory acute myeloid leukemia patients from 2016.01.01 to 2018.10.31 in the handan first hospital blood medical treatment of blood,including 26 patients underwent traditional chemotherapy alone(HAA,HAG,the CAG,reduction of the CAG)therapy,36 patients accepted desitabine combined with traditional chemotherapy,regimened for analysis of the two groups of treatment effect and its influencing factors.Results:After 1 course of chemotherapy,the overall response rate(OR)of 36 patients in the desecitabine group was 88.9%(32/36),with no overall response rate(NR)of 11.1%(4/36).OR61.5%(16/26)and NR38.5%(10/26)of the 26 patients in the traditional treatment group,the effective rate between the two groups was analyzed with statistical significance(P= 0.011).Among the 62 patients underwent chromosome risk stratification: Low risk group: a total of 20 cases,OR100%(20/20),NR0.0%(0/0);Medium risk group: 26 cases,OR84.6%(22/26),NR15.4%(4/26);High risk group: a total of 16 cases,OR37.5%(6/16)and NR62.5%(10/16),were not tested by chi-square test and likelihood ratio analysis due to small sample size,P<0.001,the difference was statistically significant.Among the 62 patients,there were 23 middle-aged and elderly patients(age ? 60 years old)and 39 non-elderly patients.After 1 course of chemotherapy,OR 52.2%(12/23)and NR47.8%(11/23)of the elderly patients group.OR 92.3%(36/39)and NR7.7%(3/39)for non-elderly patients,the effective rate between different age groups was analyzed with statistical significance(P= 0.001).There was no statistical significance in analyzing the effect of gender on curative effect,P= 0.813.The type and incidence of adverse events were similar to that of the traditional regimen group,and no serious adverse events or chemotherapy-related deaths occurred.Conclusions:1.The combination of disitamine and traditional regimen for the treatment of relapsed refractory leukemia has a higher effective rate;2.Chromosomal risk stratification was correlated with curative effect.The lower the chromosomal risk stratification,the higher the effective rate;3.Age is correlated with curative effect,and non-elderly people have a higher effective rate than elderly people;4.There was no correlation between gender and curative effect.