| ObjectiveDiabetes high incidence and younger trend has become increasingly apparent.Diabetic retinopathy is a common microvascular complications of diabetes,which is the main cause of visual impairment and blindness in adults.To investigate the relationship between bone metabolic markers and degree of retinopathy in postmenopausal women with type 2 diabetes mellitus,and analyze the related factors.MethodsAccording to the Inclusion and Exclusion Criteria,we selected 178 cases of postmenopausal women over age of 40 with type 2 diabetes in this study,collecting the basic data,the degree of retinopathy,blood biochemical index and bone biochemical markers level,etc.According to the stage standard of retinopathy,it was divided into three groups,group A:72 cases without retinopathy stage(NDR);Group B:background retinopathy stage(BDR):57 cases;Group C:49 cases of proliferative retinopathy(PDR).According to the corresponding statistical processing method,three groups of patients were retrospectively analyzed about the correlation between degree of retinopathy and blood biochemical index,general situation,bone metabolic biochemical markers and explore its possible mechanism.ResultsThe degree of retinopathy was not significantly correlated with age,BMI,PTH,N-MIDoc,Ca,P,Ca*P,HbA1C.With the progression of retinopathy,the course of disease,?-CTX,T-PINP became upward trend,and C peptide,VitD-T,right forearm BMD,T score decreased gradually,and there was a significant difference between the groups(P<0.05).Spearman correlation analysis showed that the course of disease was negatively correlated with BMD and T values of right forearm,C-peptide was positively correlated with ViTD-T,and HbA1C was negatively correlated with PTH,N-MIDoc and T-PINP.ConclusionThe biochemical markers of bone metabolism in postmenopausal women with type 2 diabetes have a significant correlation with the degree of retinopathy,indicating that diabetic osteopathy is another form of diabetic microvascular disease. |
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