| Objective:Vitiligo is a skin pigmentation caused by melanin synthesis disorder.Tyrosinase is a key enzyme in the synthesis of melanin.So,tyrosinase activity plays a crucial role in the pathogenesis of pigmented disorders.Vitiligo does not generally involve other systemic diseases and it’s the most important consequences is the psychological impact.Vitiligo will have a strong influence on the self-esteem of the patient,which leads to severe depression and the sharp consciousness of the society to lead to the quality of life.So,it has the subjective necessity of treatment.In addition,In various studies based population show that the prevalence rate of vitiligo was 0.5% to 1% in the world.The incidence of vitiligo is rising under social life and learning pressure.There was two objectives in this articles,One was to observe the clinical efficacy of the treatment for vitiligo by Qubai copper and a rational drug scheme will be selected for the treatment of pigment synthesis disorder disease.The other was to observe the clinical efficacy of the treatment for vitiligo which caused by primary white spot with trauma and treatment by Qubai copper then a new therapeutic regimen can be used when in the aforementionedsituation.Methods:All of the 90 vitiligo patients were collected since May 2016 in the department of dermatology of The Second Hospital of Jilin University,already remove pityriasis,blotch,naevus anemicus and other kinds of diseases that can make skin and mucous membranes depigmentation.We divided them into three groups equally.The combined group was given the treatment by Qubai copper and Tincture of Chinese Medicine.The traditional Chinese medicine group was given the treatment by Tincture of Chinese Medicine only and the Qubai copper group was given the treatment by Qubai copper only(the group contain the patients that with primary white spot caused by use Tincture of Chinese Medicine and ultraviolet light unreasonable).For the combined group use Qubai copper and Tincture of Chinese Medicine once every day,for the traditional Chinese medicine group use Tincture of Chinese Medicine once day,The Qubai copper group use Qubai copper once day.Continuous treatment for 4 weeks and 12 weeks.The curative effects of the three groups had been evaluated and the adverse reactions and safety indexes of the three groups were observed.Statistical analysis was conducted by SPSS 19.0.Results:1.At 4 weeks,the effective rate of the combined group(37.57%)was higher than the traditional Chinese medicine group(31.52%)and there is no statistically significant difference between two groups(P=0.242,P > 0.05).And the effective rate of the combined group(37.57%)was higher than the Qubai copper group(24.14%)and there is statistically significant difference between two groups(P=0.010,P <0.05).At 12 weeks,the effective rate of the combined group(61.27%)was higher than the traditional Chinese medicine group(49.09%)and two groups was statistically significant difference(P=0.024,P < 0.05).And the effective rate of the combined group(61.27%)was higher than the Qubai copper group(40.00%)and two groups was statistically significant difference(P=0.000,P < 0.05).2.The incidence of adverse reactions in the traditional Chinese medicine group(14.15%)was higher than the combined group(7.14%),while the incidence of adverse reactions in the Qubai copper group(0%)was lower than the combined group(7.14%).3.At 2 weeks,the rate of injury and repair was 100% in the Qubai copper group.4.Single application of Qubai copper there was no allergies.Conclusion:The curative effect of the combination Qubai copper and Tincture of Chinese Medicine on the treatment of vitiligo is better than Tincture of Chinese Medicine only and it can reduce the adverse reaction whencombined with the use of copper.Using Qubai copper to treat vitiligo was safe,effective and stable,it has certain repair and antibacterial effects for primary leukoplakia with trauma. |
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