Study On Cognitive Function And Related Factors Before And After Treatment Of Antidepressants In First-episode And Recurrent Depressive Disorder

Objective: More and more studies have shown that depression is accompanied by cognitive impairment,but the current domestic and international views on whether antidepressants can improve the cognitive function of depression are not uniform.Based on the repetitive set of neuropsychological state tests,the characteristics of cognitive function before and after treatment of antidepressant drugs in patients with first-episode and recurrent depressive disorder,and their relationship with clinical features and severity of symptoms.Methods: Rom the Hefei Fourth People’s Hospitalhospital from September 2017 to October 2018,outpatients and hospitalized first-time and recurrent depressive patients,while recruiting normal controls.All subjects were tested for neuropsychological status,general demographic data were collected,the Hamilton Depression Scale(HAMD-24)was used to assess the severity of depression,and the Hamilton Anxiety Scale(HAMA)was used to assess the severity of anxiety.To the extent,the patient’s cognitive function was assessed using a repetitive set of neuropsychological status tests.In the first-episode and recurrent depressive disorder group,8 weeks of SSRIs and SNRIs antidepressant treatment were performed to complete the HAMD-24,HAMA,and repetitive neuropsychological test.Results Statistical analysis was performed using SPSS16.0 software.Results:(1)There were significant differences in the memory,speech function,attention,time-lapse memory and RBANS total scores between the first group,the recurrent group and the normal control group(P < 0.05).Pairwise analysis found that the total scores of RBANS and RBANS in the first and second groups were lower than those in the normal control group,and the difference was statistically significant(P<0.05).The total scores of the five factors and RBANS in the first group were higher than those in the recurrence group.The immediate memory,speech function,attention,time delay memory and RBANS total scores were statistically significant between the two groups(P<0.05)Conclusions.(2)There were significant differences in immediate memory,attention,time-lapse memory and RBANS total scores between the first and recurrent groups after 8 weeks of treatment and the normal control group(P<0.05).In the first-episode group and the recurrent group,the immediate memory,delayed memory,and total RBANS scores were lower than those in the normal control group,with significant differences(P<0.05).And the attention factor in the recurrent group was significantly lower than that in the normal control group(P<0.05).In addtion the total scores of the five factors and RBANS in the first group were higher than those in the recurrent group.The visual extent,delayed memory,and total RBANS scores were statistically significant between the two groups(P<0.05).(3)Before and after treatment,patients with primary and recurrent depressive disorder had significant changes in HAMA total score,HAMD total score,RBANS scores and RBANS total scores.The difference was statistically significant(P < 0.05).(4)The HAMD partial factor score and the HAMD total score are negatively related to the RBANS partial factor score and the RBANS total score(P<0.05).Conclusion: 1.Patients with first-episode and recurrent depressive disorders not only have emotional symptoms,but also have extensive cognitive impairment,and recurrent patients have more severe cognitive dysfunction than first-person patients.2.Newantidepressants can effectively alleviate depressive symptoms and can Partially improve the cognitive function of patients.3.Cognitive impairment of depressive disorder is associated with severity of symptoms.