Analysis And Research On The Influencing Factors Of Gestational Trophoblastic Diseases

Objective:To investigate the pathogenesis and epidemiological characteristics of the gestational trophoblastic disease,and to screen out the risk factors related to the gestational trophoblastic disease,so as to improve the understanding and prevention of the disease.Methods:Analysis by retrospective survey method in January 2008-December 2017 in Xinjiang Uygur Autonomous Region Peopled Hospital treated gravid trophocyte diseases in 152 cases,and design a 1:1 matched case-control study,to investigate the related factors were retrospectively,the comparison of measurement data with paired t test,counting data using 2 test,for there are statistically significant factors fUrther using the method of multi-factor conditional Logistic regression analysis,screening of risk factors.Results:Compared with no pregnancy history,patients with a first pregnancy increased their risk by 2.711 times(OR=2.711,95%CI:1.148?6.399),those with a second pregnancy increased their risk by 3.151 times(OR=3.151,95%CI:1.187?8.364),and those with a third pregnancy increased their risk by 2.336 times(OR=2.336,95%CI:1.235?4.418),those more than 4 pregnancies increased their risk by 3.871 times(OR=3.871,95%CI:1.333?11.245).Women with a history of hydatidiform mole had an increased risk(OR=1.770,95%CI:1.036?3.022).Women living in rural areas were at high risk(ORF=4.307,95%CI:1.26?14.715).Compared with those with a primary school education OR below,those with a bachelors degree OR above had a lower risk(OR=0.119,95%CI:0.031?0.455).Compared with the unemployed,farmers were at higher risk of disease(OR=9.546,95%CI:1.989?45.823).Among 152 cases of pregnancy trophoblastic diseases,the main clinical manifestations were postmenopausal genital bleeding in 125 cases,accounting for 82%.All the 92 patients with invasive hydatidiform mole had a previous pregnancy history,of which 89(96.74%)were secondary to hydatidiform mole.Conclusion:Trophoblastic diseases of pregnancy are related to educational level,occupational type,number of pregnancies,hydatidiform mole history and place of residence.Irregular vaginal bleeding after menopause is the most important clinical manifestation of pregnancy trophoblastic disease.Hydatidiform mole has the tendency of malignant transformation.Early diagnosis,treatment and strict follow-up are of great importance.To correctly understand the clinical characteristics of pregnancy trophoblastic diseases and to study the related risk factors,so as to prevent and detect the occurrence of pregnancy trophoblastic diseases at an early stage.