Preparation And Properties Of Polydopamine Modified Sulfonated Polyetheretherketone

Introduction:With the the continuous progress and development of materials science,biomedicine and tissue engineering technology,the performance of biomedical materials has made a qualitative leap,and its application in the medical field is more and more extensive.Biomedical materials have direct contact with human tissues and organs,so their basic performance requirements are that they have good chemical stability and do not produce toxicity to the body,ideal biomedical materials should also have good antimicrobial and biological activity,and can establish good osteointegration at the tissue interface.Polyether ether ketone(PEEK)as a new type of polymer material,has good mechanical properties,but the surface of PEEK is inadequate in bioactivity and can not establish a stable osseointegration with the tissue.Surface modification of PEEK can improve the biocompatibility of the surface on the premise of maintaining the mechanical properties to the greatest extent,which is the focus of current research.PEEK was modified by surface sulfonation and polydopamine coating,and the biological activity of PEEK was studied.Purposes:In this experiment,the surface modification of PEEK materials was carried out by concentrated sulfuric acid and polydopamine coating.The effects of different surface modification methods on the biological activity of PEEK materials were compared and evaluated by co-culture of cells.The theoretical basis for the wide application of PEEK materials in biomedical materials was provided.Method:Firstly,by observing the surface morphology of PEEK with different sulfonation time,a more suitable treatment time of concentrated sulfuric acid on PEEK surface was selected.PEEK and SPEEK were immersed in the hydrochloric acid buffer solution of dopamine to obtain polydopamine coating.The experiment was set up as PEEK,SPEEK,PDA/PEEK and PDA/SPEEK groups.The surface of the modified material was characterized by scanning electron microscopy,water molecule contact angle measurement and X-ray photoelectron spectroscopy.Cell adhesion,scanning electron microscopy(SEM)and cell proliferation assay were used to evaluate the cell activity on the surface of four groups of materials.Results:1.Scanning electron microscope observation and water molecule contact angle analysis of SPEEK with different acidification treatment time were carried out.Taking into account comprehensively,6 minutes was selected as the acidification treatment time of SPEEK.2.SPEEK with network-like microporous structure was obtained after acidification for 6 minutes.The contact angle increased from 85.0°±3.160°to 108.5°±2.18° and the surface hydrophilicity decreased.The contact angle of PDA/PEEK was 25.7°±1.23°,the hydrophilicity increased,the contact angle of PDA/SPEEK decreased to 35.3°±3.50°,the hydrophilicity increased.3.The results of cell adhesion,scanning electron microscopy and cell proliferation assay showed that the cell compatibility of SPEEK,PDA/PEEK and PDA/SPEEK was better than that of PEEK.Conclusion:Sulfonation modification and polydopamine coating of PEEK can construct network microporous structure and polydopamine biological coating on the surface of PEEK to improve the surface biological activity of PEEK material.