| Purpose:Depression is not only a psychiatric disease,but also the most frequently reported comorbidity among patients with epilepsy.This study aimed to investigate the prevalence and predictors of depression in a cohort of adult patients with newly diagnosed epilepsy living in Jilin Province.Methods:This is a prospective study.Data were consecutively collected outpatients with epilepsy,which attending the epilepsy outpatient department of the First Hospital of Jilin University in Jilin Province.Patients were screened using the Hamilton Rating Scale for Depression(HAM-D)or the Chinese version of the Neurological Disorders Depression Inventory for Epilepsy(C-NDDI-E).Demographic,epilepsy details,social status and psychiatric characteristics were the explanatory variables.The significant variables of univariate analysis were included in non-conditional logistic regression for multivariate analysis.Results:A total of 604 adult patients with newly diagnosed epilepsy were screened.404 patients met the criteria for admission and were divided into depression group(158;39.1%)and non-depression group(246;60.9%).Univariate analysis showed that there were significant differences in female,smoking history,status epilepticus(SE)history,headache history and low self-assessment quality of life questionnaire(SF-12)scores between the two groups.Multivariate analysis revealed that quitting tobacco(p=0.019;odds ratio [OR]=2.787;95% CI :1.180-6.586)),interictal headache(p=0.049;OR=1.873;95% CI :1.003-3.497)and the lower scores of SF-12(p<0.001;OR=0.938;95% CI :0.924-0.953)were statistically significant and became predictors of depression in adult patients with newly diagnosed epilepsy.Conclusion:The prevalence of depression in adult patients with newly diagnosed epilepsy is 39.1%.The predictors of depression in adult patients with newly diagnosed epilepsy were quitting tobacco,interictal headache and reduced quality of life. |
