Analysis Of Target Organ Damage And Its Risk In Patients With Hypertension Complicated With Hyperuricemia

BackgroundEssential hypertension is a cardiovascular syndrome characterized by elevated systemic arterial blood pressure.The common risk factors for hypertension include weight and dyslipidemia.Hyperuricemia is also a risk factor for hypertension,and it often promotes the development and progression of hypertension with other risk factors.Hypertensive target organ damage is mainly manifested in the heart,brain,kidney and retina.Hyperuricemia is a metabolic disease caused by a metabolic disorder that causes an increase in serum uric acid levels.Hyperuricemia is not only related to cardiovascular and cerebrovascular diseases such as hypertension,coronary heart disease,and stroke,but also affects the function of other organs such as the kidney seriously.At present,there are few studies on the risk analysis of target organ damage caused by hypertension complicated with hyperuricemia.Therefore,more clinical studies are needed to analyze the effects of hyperuricemia with hyperuricemia on target organs and the factors affecting target organs.Objective To explore the risk analysis of target organs and the possible risk factors in patients with hypertension complicated with hyperuricemia,and to provide evidence for prevention of hypertension and hyperuricemia and the protection of target organs.Methods The clinical data of 248 hypertensive patients admitted to our department of cardiology from January 2017 to November 2018 were collected.They were divided into high blood pressure combined with hyperuricemia group(116 cases)with the average age(57.96±18.37)years old;simple hypertension group(132 cases)with the average age(58.55±14.75)years old,according to the diagnostic criteria of hypertension and hyperuricemia,and the patient's uric acid results.Record the general data of the subjects(including age,gender,height and weight),measure the systolic and diastolic blood pressure of the subjects,and measure the blood lipid levels of the subjects(including total cholesterol,triglycerides,high-density lipoprotein,low-density lipids),renal function indicators(including blood uric acid,serum creatinine,urea nitrogen and glomerular filtration rate),Angiotensin-related hormones(aldosterone,angiotensin II,renin,cortisol and adrenocorticotropic hormone).The meaningful indicators were determined by comparing to differences between the relevant clinical indicators of the two groups of patients were.Multivariate logistic regression analysis was used to further analyze the correlation between the above-mentioned meaningful indicators and hypertension complicated with hyperuricemia.The target organ damage was compared between the two groups.Results1.The body mass index and sex ratio(25.54±5.48kg/m2,79/37)in the hypertensive patients complicated with hyperuricemia were higher than those in the simple hypertension group(23.42±3.47kg/m~2,75/57).The difference was statistically significant,(P<0.05).2.In hypertension combined with hyperuricemia group,triglyceride and creatinine(1.93±1.50mmol/L,98.11±51.18?mol/L)were higher than in hypertension group(1.55±1.05mmol/L,71.70±48.41?mol/L).The high-density lipoprotein and glomerular filtration rate(0.97±0.26mmol/L,80.8±32.4mL/min/1.73m~2)in the hypertensive patients with hyperuricemia group was lower than that in the simple hypertension group(1.18±0.32mmol/L,97.6±17.7mL/min/1.73 m~2).The differences were statistically significant,(P<0.05).3.Angiotensin II(178.44±82.43 pg/mL)was significantly higher in the hypertensive patients with hyperuricemia than in the simple hypertension group(137.02±30.29pg/mL).The differences were statistically significant,(P<0.05).4.Multivariate logistic regression analysis showed that:lower levels of HDL and eGFR were independent risk factors for hypertension complicated with hyperuricemia,[OR=0.142,95%CI:0.031-0.645;OR=0.96,95%CI:0.936-0.985;(P<0.05).5.In the comparison of the incidence of target organ damage,coronary heart disease,renal insufficiency and heart failure(24.5%,26.5%,16.4%)in the hypertensive patients complicated with hyperuricemia were higher than those in the simple hypertension group(12.1%,9.8%,9.1%).Conclusionlower levels of HDL and eGFR are risk factors for hypertension complicated with hyperuricemia.It should be actively tested to prevent the development of disease,reduce the risk of hypertension and hyperuricemia,and further worsen the disease,causing target organs damage.For hypertensive patients complicated with hyperuricemia,rational use of drugs,coronary heart disease,heart failure and renal insufficiency should be actively prevented.